Infectious Complications in Pancreas Transplantation
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Purpose of Review
In addition to the infectious risk associated with all solid organ transplants, pancreas transplantation poses some unique risks associated with surgical technique and host risk factors. This review highlights several key areas of infectious diseases that physicians must consider in patients undergoing pancreas transplantation.
Surgical site infections are common after pancreas transplantation, and empiric antimicrobials, including antifungal coverage, are often needed to reduce the risk of these infections. Cytomegalovirus and Epstein-Barr virus (EBV) infections require close monitoring post-transplant, and we are just beginning to understand risk factors for post-transplant lymphoproliferative disorder, which is often associated with EBV infection in these patients.
Pancreas transplantation can be a successful cure for diabetes, if post-transplant complications, including rejection and infection, can be appropriately managed. Recent use of pancreata from HIV- and HCV-positive donors has increased the pool of possible donors, and ideally, more centers will begin to use these organs. Islet cell transplantation and xenotransplantation are exciting new avenues of research for potential diabetes cures.
KeywordsPancreas transplantation Pre-transplant vaccination Fungal infections CMV EBV Surgical site infections Donor-derived infections
Compliance with Ethical Standards
Conflict of Interest
Emily Blumberg declares grants from Merck and Shire and serves on Merck’s Scientific Advisory Committee. Jeffrey Doyon declares no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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