Current Transplantation Reports

, Volume 4, Issue 4, pp 294–303 | Cite as

Report (2017) of the International Registry on Hand and Composite Tissue Allotransplantation (IRHCTT)

  • Palmina PetruzzoEmail author
  • Claudia Sardu
  • Marco Lanzetta
  • Jean Michel Dubernard
Vascularized Composite Allografts (L Cendales and R Barth, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Vascularized Composite Allografts


Purpose of Review

Analysis of all upper extremity (UET) and face allotransplantations (FT) reported to the International Registry on Hand and Composite Tissue Transplantation (IRHCTT) by May 2017.

Recent Findings

The IRHCTT includes 66 cases of UET (18 unilateral and 38 bilateral) and 30 of FT. Acute and chronic rejections were reported in the presence of immunosuppression. Complications similar to those reported in solid organ transplantation occurred. UET patient survival was 96.7% at 1, 5, and 10 years after transplantation; graft survival was 90.4% at 1 year and 86.6% at 5 and 10 years. FT patient survival was 96.6% at 1 year and 96.2% at 5 years; graft survival was 96.6% at 1 and 5 years. The majority of UET and FT recipients were satisfied of their graft.


UET and FT are complex procedures requiring long-life immunosuppression; their success requires the patients’ careful selection, through evaluation, follow-up and compliance to the immunosuppression.


Vascularized composite allotransplantation Upper extremity allotransplantation Face allotransplantation Immunosuppressive treatment Outcomes Patient and graft survival 


Compliance with Ethical Standards

Conflict of Interest

P.P., C.S., M.L., and J.M.D. declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Palmina Petruzzo
    • 1
    • 2
    Email author
  • Claudia Sardu
    • 3
  • Marco Lanzetta
    • 4
  • Jean Michel Dubernard
    • 1
  1. 1.Department of TransplantationHopital Edouard HerriotLyonFrance
  2. 2.Department of SurgeryUniversity of CagliariCagliariItaly
  3. 3.Department of Medical Sciences and Public HealthUniversity of CagliariCagliariItaly
  4. 4.Italian Institute of Hand SurgeryMonzaItaly

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