Current Transplantation Reports

, Volume 3, Issue 3, pp 192–198 | Cite as

Lung Transplant Rejection and Surveillance in 2016: Newer Options

  • Mark Benzimra
  • Allan R. Glanville
Thoracic Transplantation (J Kobashigawa, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Thoracic Transplantation


Lung allograft rejection is a major risk factor for the development of chronic lung allograft dysfunction. It is a significant cause of morbidity and mortality, and limits survival post lung transplantation, which is lower than any other solid organ transplant. The invasive nature of current methods of diagnosis which consists of histological diagnosis via transbronchial biopsy and the lack of sensitivity of clinical surveillance warrants the search for novel less invasive and more accurate methods of diagnosis. This review aims to highlight recent changes to current methods of surveillance and diagnosis as well as present some of the novel methods that are becoming available.


Lung transplant Rejection Surveillance Acute cellular rejection Antibody-mediated rejection 


Compliance with Ethical Standards

Conflict of Interest

Mark Benzimra and Allan Glanville declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.



Acute cellular rejection


Antibody-mediated rejection


Bronchoalveolar lavage fluid


Bronchiolitis obliterans syndrome


Chronic lung allograft dysfunction


Collagen V


Donor specific HLA antibodies


Human leucocyte antigen


K-alpha-1 tubulin


Lung transplantation


Mean fluorescence intensity


Micro-ribonucleic acid


Obliterative bronchiolitis


Restrictive chronic lung allograft dysfunction


Single-antigen beads


Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  • Mark Benzimra
    • 1
  • Allan R. Glanville
    • 1
  1. 1.St Vincent’s HospitalSydneyAustralia

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