Abstract
Purpose of Review
Cardiovascular diseases exert a wide-reaching epidemiological impact as the number one cause of death worldwide. Emerging technologies such as big data and artificial intelligence (AI) are poised to significantly change the field of cardiology. However, their applications are still emerging. We aimed to define the role of big data and AI in cardiovascular disease with a focus on research.
Recent Findings
There are zettabyte levels (1021 bytes) of big data in the US that can be directed towards healthcare research. There are applications of big data analytics already being put to use with genomics, heart failure readmissions, echocardiography, and many other areas within cardiology.
Summary
We profile in this paper an extensive listing of various datasets used throughout the globe to study big data. Within cardiology, there is tremendous potential for the application of big data analytics in personalized patient care; however, they still require validation.
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References
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Centers for Disease Control and Prevention. U.S. Department of Health & Human Services. Leading causes of death: 2016. Available from: https://www.cdc.gov/nchs/fastats/leading-causes-of-death.htm. Accessed 12 Feb 2019.
Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008;359(21):2195–207.
Dilsizian ME, Siegel EL. Machine meets biology: a primer on artificial intelligence in cardiology and cardiac imaging. Curr Cardiol Rep. 2018;20(12):139.
Dunbar SB, Khavjou OA, Bakas T, Hunt G, Kirch RA, Leib AR, et al. Projected costs of informal caregiving for cardiovascular disease: 2015 to 2035: a policy statement from the American Heart Association. Circulation. 2018;137(19):e558–e77.
•• Krittanawong C, Johnson KW, Hershman SG, Tang WHW. Big data, artificial intelligence, and cardiovascular precision medicine. Expert Review of Precision Medicine and Drug Development. 2018;3(5):305-17.Important article highlighting big data technologies.
Harrell FE Jr, Lee KL, Mark DB. Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med. 1996;15(4):361–87.
D'Agostino RB Sr, Pencina MJ, Massaro JM, Coady S. Cardiovascular disease risk assessment: insights from Framingham. Glob Heart. 2013;8(1):11–23.
•• Krittanawong C, Zhang H, Wang Z, Aydar M, Kitai T. Artificial intelligence in precision cardiovascular medicine. J Am Coll Cardiol. 2017;69(21):2657–64. Important article highlighting big data technologies.
•• Rumsfeld JS, Joynt KE, Maddox TM. Big data analytics to improve cardiovascular care: promise and challenges. Nat Rev Cardiol. 2016;13(6):350–9. Important article highlighting big data technologies.
Raghupathi W, Raghupathi V. Big data analytics in healthcare: promise and potential. Health Inf Sci Syst. 2014;2:3.
Diebold FX. On the origin(s) and development of the term ‘Big Data’ 2012. Available from: https://doi.org/10.2139/ssrn.2152421. Accessed 15 Apr 2019.
Kim J. Big data, health informatics, and the future of cardiovascular medicine. J Am Coll Cardiol. 2017;69(7):899–902.
Bellazzi R. Big data and biomedical informatics: a challenging opportunity. Yearb Med Inform. 2014;9:8–13.
Capgemini. The deciding factor: big data & decision making 2013 [Available from: https://www.capgemini.com/wp-content/uploads/2017/07/The_Deciding_Factor__Big_Data___Decision_Making.pdf]. Accessed 12 Feb 2019.
Simply Ted. How to visualize data 2005 [Available from: http://simplyted.blogspot.com/2005/12/how-to-visualize-data.html]. Accessed 16 Apr 2019.
Scruggs SB, Watson K, Su AI, Hermjakob H, Yates JR 3rd, Lindsey ML, et al. Harnessing the heart of big data. Circ Res. 2015;116(7):1115–9.
American College of Cardiology. NCDR: American College of Cardiology; [2018. Available from: https://cvquality.acc.org/NCDR-Home]. Accessed 12 Feb 2019.
Hemingway H, Asselbergs FW, Danesh J, Dobson R, Maniadakis N, Maggioni A, et al. Big data from electronic health records for early and late translational cardiovascular research: challenges and potential. Eur Heart J. 2018;39(16):1481–95.
Weber GM, Mandl KD, Kohane IS. Finding the missing link for big biomedical data. JAMA. 2014;311(24):2479–80.
Anker S, Asselbergs FW, Brobert G, Vardas P, Grobbee DE, Cronin M. Big data in cardiovascular disease. Eur Heart J. 2017;38(24):1863–5.
Glicksberg BS, Johnson KW, Dudley JT. The next generation of precision medicine: observational studies, electronic health records, biobanks and continuous monitoring. Hum Mol Genet. 2018;27(R1):R56–62.
Lima FV, Fahed AC. Harnessing the power of big data in cardiovascular disease 2018 [Available from: https://www.acc.org/latest-in-cardiology/articles/2018/04/17/12/42/harnessing-the-power-of-big-data-in-cardiovascular-disease]. Accessed February 13, 2019.
American College of Cardiology. NCDR CathPCI Registry [Available from: https://cvquality.acc.org/NCDR-Home/registries/hospital-registries/cathpci-registry]. Accessed 12 Feb 2019.
American Society of Nuclear Cardiology and American Society of Echocardiography. ImageGuide Registry [Available from: http://imageguideregistry.org/]. Accessed 12 Feb 2019.
American Heart Association. AHA Approved Data Repositories [Available from: https://professional.heart.org/professional/ResearchPrograms/UCM_461443_AHA-Approved-Data-Repositories.jsp]. Accessed 12 Feb 2019.
American Heart Association. Open Science Policy Statements for AHA Funded Research 2018 [Available from: https://professional.heart.org/professional/ResearchPrograms/AwardsPolicies/UCM_461225_Open-Science-Policy-Statements-for-AHA-Funded-Research.jsp]. Accessed 12 Feb 2019.
Gaziano JM, Concato J, Brophy M, Fiore L, Pyarajan S, Breeling J, et al. Million veteran program: a mega-biobank to study genetic influences on health and disease. J Clin Epidemiol. 2016;70:214–23.
Guo X, Vittinghoff E, Olgin JE, Marcus GM, Pletcher MJ. Volunteer participation in the health eHeart study: a comparison with the US population. Sci Rep. 2017;7(1):1956.
Stanford Medicine. Apple Heart Study 2019. [Available from: https://med.stanford.edu/appleheartstudy.html]. Accessed 12 Feb 2019.
McConnell MV, Shcherbina A, Pavlovic A, Homburger JR, Goldfeder RL, Waggot D, et al. Feasibility of obtaining measures of lifestyle from a smartphone app: the MyHeart counts cardiovascular health study. JAMA Cardiol. 2017;2(1):67–76.
Krumholz HM. Big data and new knowledge in medicine: the thinking, training, and tools needed for a learning health system. Health Aff (Millwood). 2014;33(7):1163–70.
Bates DW, Saria S, Ohno-Machado L, Shah A, Escobar G. Big data in health care: using analytics to identify and manage high-risk and high-cost patients. Health Aff (Millwood). 2014;33(7):1123–31.
•• Shameer K, Johnson KW, Glicksberg BS, Dudley JT, Sengupta PP. Machine learning in cardiovascular medicine: are we there yet? Heart. 2018;104(14):1156–64. Important article highlighting big data technologies.
•• Jordan MI, Mitchell TM. Machine learning: trends, perspectives, and prospects. Science. 2015;349(6245):255–60. Important article highlighting big data technologies.
•• Esteva A, Robicquet A, Ramsundar B, Kuleshov V, DePristo M, Chou K, et al. A guide to deep learning in healthcare. Nat Med. 2019;25(1):24–9. Important article highlighting big data technologies.
•• Johnson KW, Torres Soto J, Glicksberg BS, Shameer K, Miotto R, Ali M, et al. Artificial intelligence in cardiology. J Am Coll Cardiol. 2018;71(23):2668–79. Important article highlighting big data technologies.
Towards Data Science. Machine Learning 101, Supervised, Unsupervised, Reinforcement, & Beyond in 2017 [Available from: https://towardsdatascience.com/machine-learning-101-supervised-unsupervised-reinforcement-beyond-f18e722069bc]. Accessed 16 Apr 2019.
Brownlee J. Supervised and unsupervised machine learning algorithms 2016. Available from: https://machinelearningmastery.com/supervised-and-unsupervised-machine-learning-algorithms/. Accessed 16 Apr 2019.
Das S. Deep learning 101 2019. Available from: https://towardsdatascience.com/deep-learning-101-a53e3caf31b1. Accessed 16 Apr 2019.
Costa CM, Silva IS, de Sousa RD, Hortegal RA, Regis CDM. The association between reconstructed phase space and artificial neural networks for vectorcardiographic recognition of myocardial infarction. J Electrocardiol. 2018;51(3):443–9.
McCabe JM, Armstrong EJ, Ku I, Kulkarni A, Hoffmayer KS, Bhave PD, et al. Physician accuracy in interpreting potential ST-segment elevation myocardial infarction electrocardiograms. J Am Heart Assoc. 2013;2(5):e000268.
Fornell D. Applications for artificial intelligence in cardiovascular imaging. 2019 [Available from: https://www.dicardiology.com/article/applications-artificial-intelligence-cardiovascular-imaging]. Accessed 12 Feb 2019.
Imran TF, Posner D, Honerlaw J, Vassy JL, Song RJ, Ho YL, et al. A phenotyping algorithm to identify acute ischemic stroke accurately from a national biobank: the Million Veteran Program. Clin Epidemiol. 2018;10:1509–21.
Sanchez-Martinez S, Duchateau N, Erdei T, Fraser AG, Bijnens BH, Piella G. Characterization of myocardial motion patterns by unsupervised multiple kernel learning. Med Image Anal. 2017;35:70–82.
Shah SJ, Katz DH, Selvaraj S, Burke MA, Yancy CW, Gheorghiade M, et al. Phenomapping for novel classification of heart failure with preserved ejection fraction. Circulation. 2015;131(3):269–79.
Cikes M, Sanchez-Martinez S, Claggett B, Duchateau N, Piella G, Butakoff C, et al. Machine learning-based phenogrouping in heart failure to identify responders to cardiac resynchronization therapy. Eur J Heart Fail. 2019;21(1):74–85.
Bayati M, Braverman M, Gillam M, Mack KM, Ruiz G, Smith MS, et al. Data-driven decisions for reducing readmissions for heart failure: general methodology and case study. PLoS One. 2014;9(10):e109264.
Mortazavi BJ, Downing NS, Bucholz EM, Dharmarajan K, Manhapra A, Li SX, et al. Analysis of machine learning techniques for heart failure readmissions. Circ Cardiovasc Qual Outcomes. 2016;9(6):629–40.
•• Gandhi S, Mosleh W, Shen J, Chow CM. Automation, machine learning, and artificial intelligence in echocardiography: a brave new world. Echocardiography. 2018;35(9):1402–18. Important article highlighting big data technologies.
Thavendiranathan P, Liu S, Verhaert D, Calleja A, Nitinunu A, Van Houten T, et al. Feasibility, accuracy, and reproducibility of real-time full-volume 3D transthoracic echocardiography to measure LV volumes and systolic function: a fully automated endocardial contouring algorithm in sinus rhythm and atrial fibrillation. J Am Coll Cardiol Img. 2012;5(3):239–51.
Sengupta PP, Huang YM, Bansal M, Ashrafi A, Fisher M, Shameer K, et al. Cognitive machine-learning algorithm for cardiac imaging: a pilot study for differentiating constrictive pericarditis from restrictive cardiomyopathy. Circ Cardiovasc Imaging. 2016;9(6).
Margolis R, Derr L, Dunn M, Huerta M, Larkin J, Sheehan J, et al. The National Institutes of Health’s Big Data to Knowledge (BD2K) initiative: capitalizing on biomedical big data. J Am Med Inform Assoc. 2014;21(6):957–8.
Denaxas SC, George J, Herrett E, Shah AD, Kalra D, Hingorani AD, et al. Data resource profile: cardiovascular disease research using linked bespoke studies and electronic health records (CALIBER). Int J Epidemiol. 2012;41(6):1625–38.
Tu JV, Chu A, Donovan LR, Ko DT, Booth GL, Tu K, et al. The Cardiovascular Health in Ambulatory Care Research Team (CANHEART): using big data to measure and improve cardiovascular health and healthcare services. Circ Cardiovasc Qual Outcomes. 2015;8(2):204–12.
Thompson SG, Willeit P. UK Biobank comes of age. Lancet. 2015;386(9993):509–10.
Weintraub WS, Fahed AC, Rumsfeld JS. Translational medicine in the era of big data and machine learning. Circ Res. 2018;123(11):1202–4.
Khera AV, Chaffin M, Aragam KG, Haas ME, Roselli C, Choi SH, et al. Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. Nat Genet. 2018;50(9):1219–24.
Weng LC, Preis SR, Hulme OL, Larson MG, Choi SH, Wang B, et al. Genetic predisposition, clinical risk factor burden, and lifetime risk of atrial fibrillation. Circulation. 2018;137(10):1027–38.
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Fabio V. Lima and Regina Druz each declare no potential conflicts of interest. Raymond Russell reports personal fees from ResTORbio, outside the submitted work. His spouse is employed by ResTORbio and also receives stock options. The company is developing novel drugs to treat pulmonary infections as well as Parkinson’s disease and therefore not related to the content of this manuscript.
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Lima, F.V., Russell, R. & Druz, R. Big Data in Cardiovascular Disease. Curr Epidemiol Rep 6, 329–346 (2019). https://doi.org/10.1007/s40471-019-00209-1
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DOI: https://doi.org/10.1007/s40471-019-00209-1