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Dielectrophoretic microfluidic device for separation of red blood cells and platelets: a model-based study

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Abstract

The paper proposes a dielectrophoresis microfluidic chip for particle separation, which uses dielectric properties to perform size-based fractionation of red blood cells and platelets. Based on the control variables, the distribution of the electric field in the chip and the trajectory of the particles in the microfluidic channel are calculated using COMSOL Multiphysics under different electrode shapes, voltages and chip exit structures. Both red blood cells and platelets respond to negative dielectrophoresis at an alternating current signal with a frequency of 100 kHz. The larger red blood cells are subjected to a stronger dielectrophoretic force than the platelets and are biased toward the right outlet, and the platelets flow out from the left outlet under the combined action of fluid force and dielectrophoretic force to achieve the purpose of separation. On this basis, through quantitative comparison and analysis, a more optimized microfluidic chip capable of effectively separating particles is finally selected.

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Acknowledgements

This work was supported by LiaoNing Revitalization Talents Program (XLYC1907122), Liaoning Natural Science Foundation (2019-MS-169). We sincerely thank Prof. Chong Liu for his kind guidance.

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All authors designed and performed the numerical simulations. The manuscript was written through contributions from all authors. All authors have given approval to the final version of the manuscript.

Correspondence to Xueye Chen.

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All the authors declare no conflict of interest.

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Zhang, Y., Chen, X. Dielectrophoretic microfluidic device for separation of red blood cells and platelets: a model-based study. J Braz. Soc. Mech. Sci. Eng. 42, 89 (2020). https://doi.org/10.1007/s40430-020-2169-x

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Keywords

  • Comsol
  • Dielectrophoresis
  • Microfluidic chip
  • Particle separation