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Current Addiction Reports

, Volume 3, Issue 2, pp 189–198 | Cite as

Cannabis Use Disorders and Altered Brain Morphology: Where Is the Evidence?

  • Valentina LorenzettiEmail author
  • Albert Batalla
  • Janna Cousijn
Cannabis (F Filbey, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Cannabis

Abstract

Cannabis use disorders (CUDs) affect 13.1 million individuals worldwide. Brain morphology specific to CUDs may mediate the adverse behavioral outcomes of CUDs. We reviewed findings from 20 human neuroimaging studies on grey and white matter morphology in cannabis users that specifically included CUD assessments. There is evidence for CUD-specific morphological abnormalities within the striatum, medial temporal lobe, prefrontal cortex, cerebellum, and corpus callosum. Factors that may aggravate morphological abnormalities associated with CUDs include earlier onset age, higher lifetime exposure, and CUD-associated problems, while abstinence may result in (partial) recovery. These observations suggest that the neural substrates of compulsive cannabis use (e.g., striatum) may be distinct from those linked to cannabinoid exposure (e.g., hippocampus). The lack of studies examining individuals with a diagnosed CUD prevents drawing strong conclusions on CUD-specific morphological abnormalities. Comparing cannabis users with and without CUD is essential to delineate the neurobiology and inform new treatment strategies.

Keywords

Addiction Brain morphology Cannabis Cannabis use disorder Grey matter White matter 

Notes

Compliance with Ethical Standards

Conflict of Interest

Valentina Lorenzetti, Albert Batalla, and Janna Cousijn declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  • Valentina Lorenzetti
    • 1
    Email author
  • Albert Batalla
    • 2
    • 3
  • Janna Cousijn
    • 4
  1. 1.Brain & Mental Health Laboratory, Monash Institute of Cognitive & Clinical Neurosciences and School of Psychological SciencesMonash UniversityMelbourneAustralia
  2. 2.Department of PsychiatryRadboud University Medical CentreNijmegenThe Netherlands
  3. 3.Nijmegen Institute for Scientist-Practitioners in Addiction (NISPA)Radboud UniversityNijmegenThe Netherlands
  4. 4.Department of Developmental PsychologyUniversity of AmsterdamAmsterdamThe Netherlands

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