European Archives of Paediatric Dentistry

, Volume 19, Issue 1, pp 1–22 | Cite as

Biodentine™ material characteristics and clinical applications: a 3 year literature review and update

  • S. RajasekharanEmail author
  • L. C. Martens
  • R. G. E. C. Cauwels
  • R. P. Anthonappa
Systematic Review



Biodentine™ has frequently been acknowledged in the literature as a promising material and serves as an important representative of tricalcium silicate based cements used in dentistry.


To provide an update on the physical and biological properties of Biodentine™ and to compare these properties with those of other tricalcium silicate cements namely, different variants of mineral trioxide aggregate (MTA) such as ProRoot MTA, MTA Angelus, Micro Mega MTA (MM-MTA), Retro MTA, Ortho MTA, MTA Plus, GCMTA, MTA HP and calcium enriched mixture (CEM), Endosequence and Bioaggregate™.

Study design

A comprehensive literature search for publications from November 20, 2013 to November 20, 2016 was performed by two independent reviewers on Medline (PubMed), Embase, Web of Science, CENTRAL (Cochrane), SIGLE, SciELO, Scopus, Lilacs and Electronic and hand search was carried out to identify randomised control trials (RCTs), case control studies, case series, case reports, as well as in vitro and animal studies published in the English language.


The enhanced physical and biologic properties of Biodentine™ could be attributed to the presence of finer particle size, use of zirconium oxide as radiopacifier, purity of tricalcium silicate, absence of dicalcium silicate, and the addition of calcium chloride and hydrosoluble polymer. Furthermore, as Biodentine™ overcomes the major drawbacks of MTA it has great potential to revolutionise the different treatment modalities in paediatric dentistry and endodontics especially after traumatic injuries. Nevertheless, high quality long-term clinical studies are required to facilitate definitive conclusions.


Biodentine™ Tricalcium silicate 



The authors declare that no funding was received for this review.

Compliance with ethical standards

Conflict of interest

The research group received material support from Septodont, Paris, France for educational programmes intended for general dentists.


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Copyright information

© European Academy of Paediatric Dentistry 2018

Authors and Affiliations

  1. 1.Department of Paediatric Dentistry and special care, PAECOMEDIS Research ClusterGhent UniversityGhentBelgium
  2. 2.Paediatric Oral Health Research Group, School of DentistryThe University of Western AustraliaPerthAustralia

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