European Archives of Paediatric Dentistry

, Volume 18, Issue 3, pp 171–178 | Cite as

Retrospective evaluation of paediatric oral biopsies over a 10-year period in Western India

  • S. S. PatilEmail author
  • U. R. Kontham
  • R. K. Kontham
  • A. Chowdhery
Original Scientific Article



This retrospective study reviewed the paediatric oral biopsies received over 10 years at a teaching hospital and dental college in India. It is important that paediatric dentists know the diagnostic tendencies of oral pathological conditions in children, and possess updated information for their diagnosis and treatment.


Biopsies of patients 17 years of age or younger were selected. Computerised data regarding age, gender, anatomic location, and histopathological diagnosis was retrieved and classified into nine categories.


Of a total 2959 oral biopsies, 359 cases (12.1%) were in the paediatric population with a slight male predominance. Salivary gland pathology (21.4%) was most frequently observed followed by dental pathology, maxillofacial tumours and maxillofacial cysts. More than a third of cases (35.9%) were found to occur in the mandible. Five cases of malignancies were found, two of which were salivary gland tumours.


The majority of lesions identified were of a benign nature necessitating minimal intervention; however, it is important to recognise that malignant lesions can occur in children. Any swelling, especially related to the salivary glands, must be investigated immediately, so as to prevent mortality and reduce morbidity. Diverse classifications used by previous authors make comparison of data challenging.


Oral pathology Biopsy Oral diagnosis Paediatric 



The authors would like to thank Dr. S. Kheur, Head of Dept. Oral and Maxillofacial Pathology, Dr. D. Y. Patil Dental College and Hospital, for her invaluable support in carrying out the present study.

Compliance with ethical standards


The present study was not funded.

Ethical approval

The study was approved by the Ethics Committee of the institution (DYPDCH/IESC/01/2016).

Conflict of interest

The authors declare that they have no conflict of interest.


  1. Arotiba GT. A study of orofacial tumors in Nigerian children. J Oral Maxillofac Surg. 1996;54:34–8.CrossRefPubMedGoogle Scholar
  2. Barnes L, Eveson J, Reichart P, Sidransky D. World Health Organization classification of tumours: pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005.Google Scholar
  3. Cavalcante RB, Buratti E, Daniel AP, de Alencar GF, Chen Z. Retrospective review of oral and maxillofacial pathology in a Brazilian paediatric population. Eur Arch Paediatr Dent. 2016;17(2):115–22.CrossRefPubMedGoogle Scholar
  4. Chen YK, Lin LM, Huang HC, Lin CC, Yan YH. A retrospective study of oral and maxillofacial biopsy lesions in a pediatric population from southern Taiwan. Pediatr Dent. 1998;20(7):404–10.PubMedGoogle Scholar
  5. Chi AC, Lambert PR, Richardson MS, et al. Oral mucoceles: a clinicopathologic review of 1,824 cases, including unusual variants. J Oral Maxillofac Surg. 2011;69:1086–93.CrossRefPubMedGoogle Scholar
  6. Das S, Das AK. A review of pediatric oral biopsies from a surgical pathology service in a dental school. Pediatr Dent. 1993;15(3):208–11.PubMedGoogle Scholar
  7. Dhanuthai K, Banrai M, Limpanaputtajak S. A retrospective study of paediatric oral lesions from Thailand. Int J Paediatr Dent. 2007;17:248–53.CrossRefPubMedGoogle Scholar
  8. Dovigi E, Kwok EYL, Eversole LR, Dovigi A. A retrospective study of 51,781 adult oral and maxillofacial biopsies. JADA. 2016;147(3):170–6.PubMedGoogle Scholar
  9. Gonzalez-Alva P, Tanaka A, Oku Y, et al. Keratocystic odontogenic tumor: a retrospective study of 183 cases. J Oral Sci. 2008;50(2):205–12.CrossRefPubMedGoogle Scholar
  10. Gültelkin SE, Tokman B, Türkseven MR. A review of pediatric oral biopsies in Turkey. Int Dent J. 2003;53:26–32.CrossRefPubMedGoogle Scholar
  11. Ha WN, Kelloway E, Dost F, et al. A retrospective analysis of oral and maxillofacial pathology in an Australian paediatric population. Aust Dent J. 2014;59:221–5.CrossRefPubMedGoogle Scholar
  12. Jones AV, Franklin CD. An analysis of oral and maxillofacial pathology found in children over a 30-year period. Int J Paediatr Dent. 2006;16(1):19–30.CrossRefPubMedGoogle Scholar
  13. Keszler A, Guglielmotti MB, Dominguez FV. Oral pathology in children. Frequency, distribution and clinical significance. Acta Odontol Latinoam. 1990;5:39–48.PubMedGoogle Scholar
  14. Krishnan R, Ramesh M, Paul G. Retrospective evaluation of pediatric oral biopsies from a dental and maxillofacial surgery centre in Salem, Tamil Nadu, India. J Clin Diagn Res. 2014;8(1):221–3.PubMedPubMedCentralGoogle Scholar
  15. Lawoyin JO. Pediatric oral surgical pathology service in African population group: a 10-year review. Odontostomatol Trop. 2000;23(89):27–30.PubMedGoogle Scholar
  16. Lei F, Chen JY, Lin LM, et al. Retrospective study of biopsied oral and maxillofacial lesions in pediatric patients from southern Taiwan. J Dent Sci. 2014;9:351–8.CrossRefGoogle Scholar
  17. Lima GS, Fontes ST, de Araújo LM, et al. A survey of oral and maxillofacial biopsies in children: a single-center retrospective study of 20 years in Pelotas-Brazil. J Appl Oral Sci. 2008;16:397–402.CrossRefPubMedCentralGoogle Scholar
  18. Maia DM, Merly F, Castro WH, et al. A survey of oral biopsies in Brazilian pediatric patients. ASDC J Dent Child. 2000;67:128–31.PubMedGoogle Scholar
  19. Martins-Filho PR, de Santana ST, Piva MR, et al. A multicenter retrospective cohort study on pediatric oral lesions. J Dent Child (Chic). 2015;82(2):84–90.Google Scholar
  20. Mathew AL, Pai KM, Sholapurkar AA, Vengal M. The prevalence of oral mucosal lesions in patients visiting a dental school in Southern India. Indian J Dent Res. 2008;19:99–103.CrossRefPubMedGoogle Scholar
  21. Saxena S, Kumar S, Pundir S. Pediatric jaw tumors: our experience. J Oral Maxillofac Pathol. 2012;16:27–30.CrossRefPubMedPubMedCentralGoogle Scholar
  22. Shah SK, Le MC, Carpenter WM. Retrospective review of pediatric oral lesions from a dental school biopsy service. Pedriatr Dent. 2009;31:14–9.Google Scholar
  23. Skinner RL, Davenport WD, Weir JC, Carr RF. A survey of biopsied oral lesions in pediatric dental patients. Pediatr Dent. 1986;8(3):163–7.PubMedGoogle Scholar
  24. Sklavounou-Andrikopoulou A, Piperi E, Papanikolaou V, Karakoulakis I. Oral soft tissue lesions in Greek children and adolescents: a retrospective analysis over a 32-year period. J Clin Pediatr Dent. 2005;29(2):175–8.CrossRefPubMedGoogle Scholar
  25. Sousa FB, Etges A, Correa L, Mesquita RA, de Araujo NS. Pediatric oral lesions: a 15-year review from Sao Paulo, Brazil. J Clin Pediatr Dent. 2002;26(4):413–8.CrossRefPubMedGoogle Scholar
  26. Vale EB, Perez FMMR, Rodrigues GLC, et al. A review of oral biopsies in children and adolescents: a clinicopathological study of a case series. J Clin Exp Dent. 2013;5(3):144–9.CrossRefGoogle Scholar
  27. Wang YL, Chang HH, Chang JY, et al. Retrospective survey of biopsied oral lesions in pediatric population. J Formos Med Assoc. 2009;108:862–71.CrossRefPubMedGoogle Scholar
  28. Züniga MD, Méndez CR, Kauterich RR, et al. Paediatric oral pathology in a Chilean population: a 15-year review. Int J Paediatr Dent. 2012;23:346–51.CrossRefPubMedGoogle Scholar

Copyright information

© European Academy of Paediatric Dentistry 2017

Authors and Affiliations

  • S. S. Patil
    • 1
    Email author
  • U. R. Kontham
    • 1
  • R. K. Kontham
    • 2
  • A. Chowdhery
    • 3
  1. 1.Department of PaedodonticsDr. D. Y. Patil Dental College and HospitalPuneIndia
  2. 2.Department of OrthodonticsNair Hospital Dental CollegeMumbaiIndia
  3. 3.Department of Oral and Maxillofacial RadiologyDr. D. Y. Patil Dental College and HospitalPuneIndia

Personalised recommendations