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European Archives of Paediatric Dentistry

, Volume 17, Issue 6, pp 435–443 | Cite as

Dental care approach in patients with osteopetrosis

  • V. Detailleur
  • G. Vansteenkiste
  • M. Renard
  • A. VerdonckEmail author
Original Scientific Article

Abstract

Aim

To describe dental and dentofacial characteristics observed in patients diagnosed with osteopetrosis and to advise a dental care approach in these patients.

Methods

Four patients were clinically diagnosed with osteopetrosis, characterised by increased bone density, bone marrow failure, blindness and deafness due to compression of cranial nerves. All patients were dentally screened at different ages (2.5–31 years) and three of them were treated with a haematopoietic stem cell transplantation (HSCT) at the age of 6 months, 1 and 3.1 years.

Results

All patients showed similar dental characteristics but varying severity and extent. Dental pits, abnormalities in form, agenesis and enamel deformations are seen. The eruption of the permanent dentition occurs at a slow rate, primary teeth can persist, have no successor, and aberrant form of the primary/permanent teeth can delay eruption. Uneven surfaces and atypical dental crowns combined with visual impairment make brushing of the teeth and plaque removal more difficult to manage.

Conclusion

Dental problems such as delay in tooth eruption, crown anomalies and agenesis are seen in the patients diagnosed with osteopetrosis, although the severity and extensiveness of the symptoms differ and possibly depend on the age of the patient at HSCT. Treatment management: Frequent dental follow-up examinations are necessary for guiding the eruption and professional dental cleanings. Aid in the eruption can be helpful. In the case of surgical interventions, an antibiotic prophylaxis is advised. A fluoride treatment can be added to prevent caries. The role of HSCT in dental findings needs further research.

Keywords

Osteopetrosis Dentistry HSCT Dental policy 

Notes

Compliance with ethical standards

Ethical approval

“All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.”

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Copyright information

© European Academy of Paediatric Dentistry 2016

Authors and Affiliations

  • V. Detailleur
    • 1
  • G. Vansteenkiste
    • 2
  • M. Renard
    • 3
  • A. Verdonck
    • 1
    Email author
  1. 1.Dept of Oral Health Sciences-OrthodonticsUniversity Hospitals Leuven, KU Leuven and DentistryLouvainBelgium
  2. 2.Dept of Oral Health Sciences-Pediatric Dentistry and Special CareUniversity Hospitals Leuven, KU Leuven and DentistryLouvainBelgium
  3. 3.Pediatric Hemato-OncologyUZ LeuvenLouvainBelgium

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