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European Archives of Paediatric Dentistry

, Volume 16, Issue 6, pp 449–454 | Cite as

Effect of a chlorhexidine/thymol and a fluoride varnish on caries development in erupting permanent molars: a comparative study

  • S. Flamee
  • S. GizaniEmail author
  • C. Caroni
  • L. Papagiannoulis
  • S. Twetman
Original Scientific Article

Abstract

Aim

To compare the caries preventive effect of a chlorhexidine/thymol-containing antibacterial varnish with a fluoride varnish when topically applied during the eruption of permanent molars.

Methods

The study group consisted of 189 patients, 5–14 years of age, with one 1st or 2nd permanent molar in the process of eruption. After stratification for type of molar and stage of eruption, the patients were randomised to either quarterly topical applications with an antibacterial varnish (Cervitec® Plus; CV group) or biannual applications with a fluoride varnish plus biannual treatments with placebo varnish (Fluor Protector; FV group). The duration of the study was 2 years. The primary endpoint was caries incidence (initial and cavitated) in the erupting molars and the secondary outcome was salivary mutans streptococci (MS) counts.

Results

The groups were balanced with respect to socio-economy, oral hygiene, dietary habits and caries experience at baseline. The dropout rate was 11.6 %. The caries incidence was low (<10 %) in both groups and there was no significant difference between the CV and FV groups with respect to occlusal caries development in the erupting molars (relative risk 1.08, 95 % CI 0.94–1.25). Significantly lower levels of salivary MS were disclosed in the CV group at the end of the study (p < 0.05).

Conclusions

No difference in occlusal caries development in young permanent molars was displayed after topical applications of either a chlorhexidine/thymol varnish or a fluoride varnish during tooth eruption.

Keywords

Antibacterial agents Children Dental varnishes Fissure caries Mutans streptococci 

Notes

Acknowledgments

The varnishes (chlorhexidine/thymol––Cervitec® and fluoride––Fluor Protector®) and the chair-side tests (CRT bacteria) were generously supplied by Ivoclar Vivadent AG, Schaan, Liechtenstein.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

All procedures performed in the study participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© European Academy of Paediatric Dentistry 2015

Authors and Affiliations

  • S. Flamee
    • 1
  • S. Gizani
    • 1
    Email author
  • C. Caroni
    • 2
  • L. Papagiannoulis
    • 1
  • S. Twetman
    • 3
  1. 1.Department of Paediatric Dentistry, Dental SchoolNational and Kapodistrian University of AthensAthensGreece
  2. 2.Department of MathematicsNational Technical University of AthensAthensGreece
  3. 3.Department of Odontology, Faculty of Health and Medical SciencesUniversity of CopenhagenCopenhagen NDenmark

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