European Archives of Paediatric Dentistry

, Volume 15, Issue 1, pp 19–26 | Cite as

Clinical evaluation of sustained-release metronidazole gel versus metronidazole solution as an intracanal medicament in abscessed primary molars

  • M. B. BhangdiaEmail author
  • B. Nandlal
  • G. S. Vijaykumar
  • P. K. Kulkarni
  • R. Shanbhog
Original Scientific Article



To evaluate the efficacy of metronidazole gel versus metronidazole solution against Enterococcus faecalis in abscessed primary molars.

Study design

A clinical trial.


Twenty pulpally involved non-vital carious human primary mandibular second molars with furcal abscess were randomly allocated into two groups to evaluate the efficacy of metronidazole gel (3 % w/v) and metronidazole solution (0.5 % w/v) against E. faecalis. Subjects in the first experimental group were subjected to treatment with metronidazole gel (3 % w/v) and subjects in the second experimental group were treated with metronidazole solution (0.5 % w/v). Two microbial samples (pre-operative and post-operative samples) were obtained from the root canals of each subject from both the groups; sub cultured and efficacy of both the groups were evaluated.


Overall percentage reduction of the mean colony forming unit (CFU) count of metronidazole gel (3 % w/v) group was 96.39 % and metronidazole solution (0.5 % w/v) was 90.90 %. Results of intergroup t test of the percentage difference of mean CFU counts between both the groups revealed a statistically highly significant difference, i.e. p value—0.008 (p < 0.01).


Metronidazole gel (3 % w/v) was more effective than metronidazole solution (0.5 % w/v) against E. faecalis.


Furcation Non-vital Metronidazole gel Metronidazole solution Enterococcus faecalis 


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Copyright information

© European Academy of Paediatric Dentistry 2013

Authors and Affiliations

  • M. B. Bhangdia
    • 1
    • 4
    Email author
  • B. Nandlal
    • 1
  • G. S. Vijaykumar
    • 2
  • P. K. Kulkarni
    • 3
  • R. Shanbhog
    • 1
  1. 1.Department of Pedodontics and Preventive DentistryJSS Dental College and Hospital, JSS UniversityMysoreIndia
  2. 2.Department of Microbiology, JSS Medical CollegeJSS UniversityMysoreIndia
  3. 3.Department of PharmaceuticsJSS College of Pharmacy, JSS UniversityMysoreIndia
  4. 4.NashikIndia

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