Clinical and Translational Imaging

, Volume 7, Issue 6, pp 427–435 | Cite as

Multimodal therapy of advanced differentiated thyroid cancer, with emphasis on the role of radioiodine

  • Alice Lorenzoni
  • Antonella Capozza
  • Alfredo Campennì
  • Luca GiovanellaEmail author
  • Ettore Seregni
Expert Review
Part of the following topical collections:
  1. Endocrine



Differentiated thyroid cancer (DTC) accounts for 95% of all thyroid cancers and is generally an indolent tumor, tending to present with limited loco-regional disease with an excellent long-term survival after treatment. However, 5–10% present with locally advanced disease and aero-digestive tract invasion or distant metastases that are the main cause of thyroid cancer-related deaths.


The present review aims to underline the complex management of advanced DTC including treatment of gross extra-thyroidal extension, recurrent loco-regional, or distant metastatic disease.


Radioiodine therapy is an effective treatment of advanced and/or metastatic DTC which contributes significantly to patients’ life expectancy. Multimodal approach based on surgical resection in combination with radioiodine therapy, interventional imaging treatment, and TSH suppression can significantly improve outcomes for this patients’ population.


Thyroid cancer Radioiodine Advanced disease Distant metastasis Advanced thyroid cancer Radioiodine therapy Local treatments Thyrosin kinase inhibitors 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Italian Association of Nuclear Medicine and Molecular Imaging 2019

Authors and Affiliations

  1. 1.Nuclear Medicine, Fondazione IRCCS Istituto Nazionale dei TumoriMilanItaly
  2. 2.Nuclear Medicine, University Hospital and University of MessinaMessinaItaly
  3. 3.Nuclear Medicine and Competence Centre for Thyroid DiseasesEnte Ospedaliero CantonaleBellinzonaSwitzerland
  4. 4.Nuclear Medicine, University Hospital and University of ZurichZurichSwitzerland

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