Clinical and Translational Imaging

, Volume 6, Issue 6, pp 449–458 | Cite as

Role of myocardial 123I-mIBG innervation imaging in the diagnosis of neurodegenerative diseases

  • Albert Flotats
Expert Review
Part of the following topical collections:
  1. Cardiovascular


Neurodegenerative diseases occur when neurons in the central and/or peripheral nervous systems lose function over time and ultimately die. They are characterized by common cellular and molecular mechanisms including protein aggregation and inclusion body formation, categorising each type of disease. Therefore, the definitive diagnosis is at post-mortem, based on pathology. However, the development of various molecular imaging techniques has enabled pathological changes to be inferred in vivo. Decreased myocardial 123I-mIBG uptake has been reported in some patients with neurodegenerative diseases. This review is aimed to synthesise the basis, methodology and clinical role of myocardial 123I-mIBG imaging in the diagnosis of certain neurodegenerative diseases, focusing on its utility to differentiate some neurodegenerative Parkinsonisms between them, and to differentiate dementia with Lewy bodies from Alzheimer’s disease and other dementias.


123I-mIBG Myocardial innervation Neurodegenerative diseases Parkinsonisms Alzheimer's disease Differential diagnosis 


Compliance with ethical standards

Conflict of interest

The author has no conflict of interest.

Ethical approval

This article is a review article and does not contain any studies with human or animal subjects performed by any of the authors.


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Copyright information

© Italian Association of Nuclear Medicine and Molecular Imaging 2018

Authors and Affiliations

  1. 1.Nuclear Medicine DepartmentUniversitat Autònoma de Barcelona, Hospital de la Santa Creu i Sant PauBarcelonaSpain

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