On the use of chance-adjusted agreement statistic to measure the assortative transmission of infectious diseases
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There have been only a small number of statistical measures to assess the assortativeness. The present study discusses the applicability of two chance-adjusted agreement statistics, kappa and AC1 as measures of the assortative transmission of infectious diseases. First, we show that the so-called assortativity coefficient corresponds to the proportion of contacts that are spent for within-group mixing in the preferential mixing formulation of heterogeneous transmission, and also that the assortative coefficient is identical to the Cohen’s kappa statistic. Second, we demonstrate that the kappa statistic is vulnerable to the paradoxes in measuring infectious disease transmission, because the assortative transmission involves not only contact heterogeneity but also other intrinsic and extrinsic factors including relative susceptibility and infectiousness. AC1 can be a useful measure due to its paradox resistant nature, and we discuss the relevance of preferential mixing formulation to the computation of AC1.
KeywordsEpidemiology Network Mathematical model Cluster Inter-observer variation
Mathematics Subject Classification (2000)Primary 92B05 Secondary 62P10
HN received funding support from the Japan Science and Technology Agency (JST) PRESTO program. KE received scholarship support from the Japan Society for Promotion of Science (JSPS). KA received funding support from the Aihara Project, the FIRST program from JSPS, initiated by CSTP. This work also received financial support from the Harvard Center for Communicable Disease Dynamics from the National Institute of General Medical Sciences (grant no. U54 GM088558) and the Area of Excellence Scheme of the Hong Kong University Grants Committee (grant no. AoE/M-12/06). The funding bodies were not involved in the collection, analysis and interpretation of data, the writing of the manuscript or the decision to submit for publication.
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