Risk Factors Associated with Failure to Achieve the Low Density Lipoprotein Cholesterol Therapeutic Target in Patients with Acute Coronary Syndrome: A Longitudinal, Single Centre Investigation
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Reducing low-density lipoprotein cholesterol (LDL-C) to target < 100 mg/dL is considered as a critical therapeutic goal after acute coronary syndrome (ACS).
To evaluate the factors associated with reaching or not this LDL-C target after 6 months of statin therapy.
Demographic features and other clinically relevant information from a cohort of patients enrolled from April 3, 2016 through March 20, 2017 were analyzed in the current investigation. All included cases had baseline LDL-C levels ≥ 100 mg/dL. LDL-C levels were determined once again after 6-month of statin therapy for each patient.
Two hundred and thirty two participants were included in the final analysis. One third of patients (33.2%) with ACS with initially elevated LDL-C failed to attain LDL-C goal at 6 months. Spearman correlation test showed that the age, diabetes mellitus, lipid lowering therapy and statin daily dose were among the influential factors associated with LDL-C goal achievement. Furthermore, multiple logistic regression analysis revealed that diabetes mellitus and statin treatment before admission were the only independent predictors of achieving LDL-C goal.
According to our findings, the drug adherence and use of higher intensity as recommended in secondary prevention are needed to increase the achievement of LDL-C treatment targets.
KeywordsAcute coronary syndrome Dyslipidemia Lipid-lowering therapy Statins Low-density lipoprotein cholesterol
We gratefully acknowledge all of the participants and entire staff involved at the Cardiology Ward of Seyyed-Alshohada Hospital for their help.
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
The study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committees of the Urmia University of Medical Sciences.
Written informed consent was obtained from all participants prior to enrollment.
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