Effect of Primary Hypertension on Treatment Outcomes of Patients with Postmenopausal Osteoporosis: A 5 Year Follow Up Retrospective Study
To investigate the efficacy of primary hypertension (HTN) on the treatment prognosis of patients with postmenopausal osteoporosis (PMOP).
45 patients who were diagnosed as PMOP with lumbar and/or femur neck bone mineral density screening (BMD) but have no history of PMOP treatment including calcium and vitamin D, have comorbid primary HTN and treated with a vasodilator antihypertensive drug at least a year were included to the study. Control group was constituted with 44 patients with PMOP at same age but have no comorbidity. Demographic features including age, height, weight, occupation, educational level menarche and menopause age, clothing style, daily intake of calcium, smoking and/or alcohol consumption, daily physical activity level, personal history of fragility fracture or in mother and duration of primary HTN diagnosis were recorded. Biochemical parameters were also recorded. Patients were treated with bisphosphonate, calcium and vitamin D and same parameters were evaluated at the end of first and fifth year.
Demographic and disease characteristics were not different between groups before treatment (p > 0.05). In group analysis, there was significant improvement in lumbar and femur neck T scores of PMOP + HT and PMOP groups after 1 and 5 years of treatment compared to baseline (p < 0.05) Lumbar and femur neck T score variations between the baseline, first and fifth years of treatment were not significantly different in PMOP + HT and PMOP groups (p < 0.05).
Although the results vary between populations, primary HTN does not have an impact on the prognosis of PMOP treatment in Turkish population.
KeywordsPrimary hypertension Postmenopausal osteoporosis Treatment
Compliance with Ethical Standards
Conflict of interest
Dr Yilmaz, Dr Umay, Dr Gundogdu and Dr Cakcı declare no disclosure or conflict of interest.
All procedures performed in this study was in accordance with the ethical standards of Turkish Ministry of Health and Diskapi Yildirim Beyazit Training and Research Hospital research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- 2.Lidfeldt J, Holmdahl L, Samsioe G, Nerbrand C, Nyberg P, Scherstén B, Agardh DC. The influence of hormonal status and features of the metabolic syndrome on bone density: a population-based study of Swedish women aged 50 to 59 years. The Women’s Health in the Lund Area Study. Metabolism. 2002;51:267–70.CrossRefGoogle Scholar
- 3.McGrowder D, Williams A, Gordon L. Hypocalciuria in pre-eclampsia and gestational hypertension due to decreased fractional excretion of calcium. Arch Med Sci. 2009;5:80–5.Google Scholar
- 12.Yilmaz V, Umay E, Gundogdu I, Tezel N. Effect of type 2 diabetes mellitus on treatment outcomes of patients with postmenopausal osteoporosis. J Diabetes Metab Disord. 2018. https://doi.org/10.1007/s40200-018-0359-1.
- 16.Yilmaz V, Umay E, Gundogdu I, Tezel N. Treatment outcomes of postmenopausal osteoporosisin patients with stable hypothyroidism: a 5 years follow up retrospective study. Erciyes Med J. 2018. https://doi.org/10.5152/etd.2018.17065.
- 18.Strazzullo P. The renal calcium leak in primary hypertension: pathophysiological aspects and clinical implications. Nutr Metab Cardiovasc Dis. 1991;1:98–103.Google Scholar