The Effects of Coenzyme Q10 Supplementation on Blood Pressures Among Patients with Metabolic Diseases: A Systematic Review and Meta-analysis of Randomized Controlled Trials
- 279 Downloads
Although several trials have assessed the effect of coenzyme Q10 (CoQ10) supplementation on blood pressures among patients with metabolic diseases, findings are controversial.
This review of randomized controlled trials (RCTs) was performed to summarize the evidence on the effects of CoQ10 supplementation on blood pressures among patients with metabolic diseases.
Randomized-controlled trials (RCTs) published in PubMed, EMBASE, Web of Science and Cochrane Library databases up to 10 August 2017 were searched. Two review authors independently assessed study eligibility, extracted data, and evaluated risk of bias of included studies. Heterogeneity was measured with a Q-test and with I2 statistics. Data were pooled by using the fix or random-effect model based on the heterogeneity test results and expressed as standardized mean difference (SMD) with 95% confidence interval (CI).
A total of seventeen randomized controlled trials (684 participants) were included. Results showed that CoQ10 supplementation significantly decreased systolic blood pressure (SBP) (SMD − 0.30; 95% CI − 0.52, − 0.08). However, CoQ10 supplementation decreased diastolic blood pressure (DBP), but this was not statistically significant (SMD − 0.08; 95% CI − 0.46, 0.29).
CoQ10 supplementation may result in reduction in SBP levels, but did not affect DBP levels among patients with metabolic diseases. Additional prospective studies regarding the effect of CoQ10 supplementation on blood pressure in patients with metabolic diseases are necessary.
KeywordsCoenzyme Q10 Blood pressure Metabolic diseases Meta-analysis
Compliance with Ethical Standards
The current study was founded by a grant from the Vice-chancellor for Research, Shiraz University of Medical Sciences, Shiraz, and Iran.
Conflict of interest
This article does not contain any studies with human participants or animals performed by any of the authors.
- 8.Yen CH, Yang NC, Lee BJ, Lin JY, Hsia S, Lin PT. The antioxidant status and concentrations of coenzyme Q10 and vitamin E in metabolic syndrome. Sci World J. 2013;2013:767968.Google Scholar
- 13.Moazen M, Mazloom Z, Dabbaghmanesh M, Ahmadi A. Effect of CoQ10 supplementation on blood pressure, inflammation, and lipid profile in type 2 diabetics. Iran J Nutr Sci Food Technol. 2013;8:145–53.Google Scholar
- 20.Mohseni M, Vafa MR, Hajimiresmail SJ, Zarrati M, Rahimi Forushani A, Bitarafan V, et al. Effects of coenzyme q10 supplementation on serum lipoproteins, plasma fibrinogen, and blood pressure in patients with hyperlipidemia and myocardial infarction. Iran Red Crescent Med J. 2014;16:e16433.CrossRefPubMedPubMedCentralGoogle Scholar
- 21.Mohammadshahi M, Farsi F, Nejad PA, Hajiani E, Zarei M, Engali KA. The coenzyme Q10 supplementation effects on lipid profile, fasting blood sugar, blood pressure and oxidative stress status among non-alcoholic fatty liver disease patients: a randomized, placebo-controlled, pilot study. J Gastroenterol Hepatol Res. 2014;3:1108–13.Google Scholar
- 24.Dai YL, Luk TH, Yiu KH, Wang M, Yip PM, Lee SW, et al. Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial. Atherosclerosis. 2011;216:395–401.CrossRefPubMedGoogle Scholar