The Effects of Coenzyme Q10 Supplementation on Blood Pressures Among Patients with Metabolic Diseases: A Systematic Review and Meta-analysis of Randomized Controlled Trials

  • Reza Tabrizi
  • Maryam Akbari
  • Nasrin Sharifi
  • Kamran B. Lankarani
  • Mahmood Moosazadeh
  • Fariba Kolahdooz
  • Mohsen Taghizadeh
  • Zatollah AsemiEmail author
Review Article



Although several trials have assessed the effect of coenzyme Q10 (CoQ10) supplementation on blood pressures among patients with metabolic diseases, findings are controversial.


This review of randomized controlled trials (RCTs) was performed to summarize the evidence on the effects of CoQ10 supplementation on blood pressures among patients with metabolic diseases.


Randomized-controlled trials (RCTs) published in PubMed, EMBASE, Web of Science and Cochrane Library databases up to 10 August 2017 were searched. Two review authors independently assessed study eligibility, extracted data, and evaluated risk of bias of included studies. Heterogeneity was measured with a Q-test and with I2 statistics. Data were pooled by using the fix or random-effect model based on the heterogeneity test results and expressed as standardized mean difference (SMD) with 95% confidence interval (CI).


A total of seventeen randomized controlled trials (684 participants) were included. Results showed that CoQ10 supplementation significantly decreased systolic blood pressure (SBP) (SMD − 0.30; 95% CI − 0.52, − 0.08). However, CoQ10 supplementation decreased diastolic blood pressure (DBP), but this was not statistically significant (SMD − 0.08; 95% CI − 0.46, 0.29).


CoQ10 supplementation may result in reduction in SBP levels, but did not affect DBP levels among patients with metabolic diseases. Additional prospective studies regarding the effect of CoQ10 supplementation on blood pressure in patients with metabolic diseases are necessary.


Coenzyme Q10 Blood pressure Metabolic diseases Meta-analysis 


Compliance with Ethical Standards


The current study was founded by a grant from the Vice-chancellor for Research, Shiraz University of Medical Sciences, Shiraz, and Iran.

Conflict of interest


Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Reza Tabrizi
    • 1
  • Maryam Akbari
    • 1
  • Nasrin Sharifi
    • 2
  • Kamran B. Lankarani
    • 3
  • Mahmood Moosazadeh
    • 4
  • Fariba Kolahdooz
    • 5
  • Mohsen Taghizadeh
    • 2
  • Zatollah Asemi
    • 2
    Email author
  1. 1.Health Policy Research Center, Institute of Health, Student Research CommitteeShiraz University of Medical SciencesShirazIslamic Republic of Iran
  2. 2.Research Center for Biochemistry and Nutrition in Metabolic DiseasesKashan University of Medical SciencesKashanIslamic Republic of Iran
  3. 3.Health Policy Research CenterShiraz University of Medical SciencesShirazIslamic Republic of Iran
  4. 4.Health Sciences Research Center, Faculty of HealthMazandaran University of Medical SciencesSariIslamic Republic of Iran
  5. 5.Indigenous and Global Health Research, Department of MedicineUniversity of AlbertaEdmontonCanada

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