Comparison of Different Obesity Indices for Predicting Incident Hypertension

  • Mohsen JanghorbaniEmail author
  • Ashraf Aminorroaya
  • Masoud Amini
Original Article



Obesity is well recognized to be an important risk factor for hypertension (HTN), but it is not clear which obesity indices have stronger association with HTN.


To evaluate the ability of different obesity indices, including visceral adiposity index (VAI), hypertriglyceridemic-waist (HTGW) phenotype, a body shape index (ABSI), body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR) and waist-to-hip ratio (WHR) as possible hypertension (HTN) predictor in a high-risk population.


Seven years follow-up data in first-degree relatives of consecutive patients with type 2 diabetes aged 30–70 years without diabetes and HTN with at least one follow-up examination (n = 1417) were analysed. Discriminatory capabilities were examined using the receiver operating characteristic (ROC) curve. Logistic regression analysis was performed to determine the strength of association between obesity indices and HTN.


Among the indices, the highest quintile compared with the lowest quintile of WHtR and WC was more strongly associated with HTN in age and sex adjusted models [odds ratio (95% CI); WHtR: 4.02 (2.36, 6.85) and WC: 3.26 (2.05, 5.20)]. Those with HTGW phenotype was 2.3 (1.54, 3.35) times more likely to develop HTN than those with normal WC normal triglyceride. On ROC curve analysis, WHtR (63.1%; 59.6, 66.7) and WC (61.7%, 58.0, 65.4) had the higher area under the ROC.


Although higher values of VAI, BMI, WHR and HTGW were associated with the risk of HTN, WHtR and WC was more strongly associated with the development of HTN, while the ABSI showed weaker association.


Visceral adiposity index Hypertriglyceridemic-waist Hypertension A body shape index Anthropometry First-degree relatives Incidence Risk factor 



We thank Mr. M. Abyar for technical computer assistance and all of the participating FDRs. This study was partly funded by the Isfahan University of Medical Sciences, Iran.

Authors contributions

MJ designed the study, performed statistical analyses and interpreted the data and drafted the manuscript; AA and MA, recruited samples, contributed to interpretation of results and revised the manuscript. All authors approved the final version submitted for publication.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflicts of interest concerning this article.

Statement of human and animal rights

This study has been approved by the Isfahan University of Medical Sciences ethical committee.

Informed consent

Informed consent was obtained from all participants for being included in the study.


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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  • Mohsen Janghorbani
    • 1
    • 2
    Email author
  • Ashraf Aminorroaya
    • 1
  • Masoud Amini
    • 1
  1. 1.Isfahan Endocrine and Metabolism Research CenterIsfahan University of Medical SciencesIsfahanIran
  2. 2.Department of Epidemiology and BiostatisticsSchool of Public Health, Isfahan University of Medical SciencesIsfahanIran

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