Molecular Diagnosis & Therapy

, Volume 20, Issue 4, pp 335–345 | Cite as

Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases

  • Amir Abbas Momtazi
  • Giuseppe Derosa
  • Pamela Maffioli
  • Maciej Banach
  • Amirhossein Sahebkar
Review Article


Curcumin is a bioactive polyphenol occurring in the rhizomes of Curcuma longa. It is well-reputed for its chemopreventive and anticancer properties; however, recent evidence has revealed numerous biological and pharmacological effects of curcumin that are relevant to the treatment of non-cancer diseases. Mechanistically, curcumin exerts its pharmacological effects through anti-inflammatory and antioxidant mechanisms via interaction with different signaling molecules and transcription factors. In addition, epigenetic modulators such as microRNAs (miRs) have emerged as novel targets of curcumin. Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases. The present systematic review was conducted to identify miRs that are regulated by curcumin in non-cancer diseases.


Curcumin Diabetic Nephropathy Curcuma Longa APOE Knockout Mouse PTP1B Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The support provided by the Iran National Science Foundation (Tehran, Iran) is gratefully acknowledged.

Compliance with Ethical Standards

Conflict of interest

Amir Abbas Momtazi, Giuseppe Derosa, Pamela Maffioli, Maciej Banach, and Amirhossein Sahebkar declare that they have no conflicts of interest.


No funding was received for this study.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Amir Abbas Momtazi
    • 1
  • Giuseppe Derosa
    • 2
    • 3
  • Pamela Maffioli
    • 3
  • Maciej Banach
    • 4
    • 5
  • Amirhossein Sahebkar
    • 6
    • 7
  1. 1.Student Research Committee, Department of Medical Biotechnology, Nanotechnology Research Center, Faculty of MedicineMashhad University of Medical SciencesMashhadIran
  2. 2.Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical ResearchUniversity of PaviaPaviaItaly
  3. 3.Department of Internal Medicine and TherapeuticsUniversity of Pavia and Fondazione IRCCS Policlinico S. MatteoPaviaItaly
  4. 4.Department of HypertensionMedical University of LodzLodzPoland
  5. 5.Healthy Aging Research Centre (HARC)Medical University of LodzLodzPoland
  6. 6.Biotechnology Research CenterMashhad University of Medical SciencesMashhadIran
  7. 7.Metabolic Research Centre, Royal Perth Hospital, School of Medicine and PharmacologyUniversity of Western AustraliaPerthAustralia

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