Molecular Diagnosis & Therapy

, Volume 18, Issue 4, pp 389–402 | Cite as

Circulating Tumor Cells in Prostate Cancer Diagnosis and Monitoring: An Appraisal of Clinical Potential

  • Giuseppe Galletti
  • Luigi Portella
  • Scott T. Tagawa
  • Brian J. Kirby
  • Paraskevi Giannakakou
  • David M. NanusEmail author
Review Article


Circulating tumor cells (CTCs) have emerged as a viable solution to the lack of tumor tissue availability for patients with a variety of solid tumors, including prostate cancer. Different approaches have been used to capture this tumor cell population and several of these techniques have been used to assess the potential role of CTCs as a biological marker to predict treatment efficacy and clinical outcome. CTCs are now considered a strong tool to understand the molecular characteristics of prostate cancer, and to be used and analyzed as a ‘liquid biopsy’ in the attempt to grasp the biological portrait of the disease in the individual patient.


Prostate Cancer Overall Survival Androgen Receptor Circulate Tumor Cell Prostate Cancer Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Acknowledgments and Disclosures

This work was supported in part by National Cancer Institute (NCI) grants CA062948, CA137020, and U54 CA143876. Luigi Portella was in part supported by the Associazione Italiana per la Ricerca sul Cancro (AIRC). Additional support was received from the Weill Cornell Clinical and Translational Science Center, the Prostate Cancer Foundation, and the Genitourinary Oncology Research Fund. The authors thank Matt Sung for kindly providing the images. The authors have no conflicts of interest that are directly relevant to the content of this article.


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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Giuseppe Galletti
    • 1
  • Luigi Portella
    • 1
  • Scott T. Tagawa
    • 1
  • Brian J. Kirby
    • 1
    • 2
  • Paraskevi Giannakakou
    • 1
  • David M. Nanus
    • 1
    • 3
    Email author
  1. 1.Division of Hematology and Medical Oncology and the Weill Cornell Cancer CenterWeill Cornell Medical CollegeNew YorkUSA
  2. 2.Sibley School of Mechanical and Aerospace Engineering, Cornell UniversityIthacaUSA
  3. 3.Division of Hematology and Medical Oncology and the Weill Cornell Cancer CenterWeill Cornell Medical CollegeNew YorkUSA

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