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Molecular Diagnosis & Therapy

, Volume 17, Issue 3, pp 147–164 | Cite as

Systematic Review of the Evidence of a Relationship Between Chronic Psychosocial Stress and C-Reactive Protein

  • Timothy V. JohnsonEmail author
  • Ammara Abbasi
  • Viraj A. Master
Review Article

Abstract

Introduction

C-reactive protein (CRP) is an acute-phase reactant with an increasing number of clinical functions. Studies in recent years have identified several social, economic, demographic, and psychological factors that contribute to baseline inflammation. Psychosocial stress represents a significant contributor to baseline inflammation. Given the importance of understanding background drivers of CRP levels, we conducted this review to assess the impact of chronic psychosocial stress on CRP levels.

Methods

Medline was searched through February 2013 for human studies examining CRP levels with respect to chronic psychosocial stress.

Results

The initial search identified 587 articles from which 129 potentially appropriate articles were reviewed. Of these 129 articles, 41 articles were included in the review. These studies were published between 2003 and 2013. Of these studies, 6 analyzed employment stress, 2 analyzed unemployment stress, 6 analyzed burnout and vital exhaustion, 6 analyzed caregiver stress, 3 analyzed interpersonal stress, 17 analyzed socioeconomic position, and 2 analyzed discrimination.

Conclusion

We conclude that psychosocial stress significantly impacts CRP and should be considered when interpreting the meaning of CRP elevations.

Keywords

Psychosocial Stress Socioeconomic Position Interpersonal Stress Caregiver Stress Vital Exhaustion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Disclosures

The authors received no funding and have no conflicts of interest that are directly relevant to the content of this article.

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Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  • Timothy V. Johnson
    • 1
    • 4
    Email author
  • Ammara Abbasi
    • 2
  • Viraj A. Master
    • 2
    • 3
  1. 1.Wills Eye InstituteThomas Jefferson UniversityPhiladelphiaUSA
  2. 2.Department of General SurgeryBeth Israel Deaconess Medical Center, Harvard Medical SchoolBostonUSA
  3. 3.Winship Cancer InstituteEmory UniversityAtlantaUSA
  4. 4.AtlantaUSA

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