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Sports Medicine

, Volume 49, Issue 6, pp 905–916 | Cite as

Acute Effects of Resistance Exercise on Cognitive Function in Healthy Adults: A Systematic Review with Multilevel Meta-Analysis

  • Jan WilkeEmail author
  • Florian Giesche
  • Kristina Klier
  • Lutz Vogt
  • Eva Herrmann
  • Winfried Banzer
Systematic Review

Abstract

Background

Recent research has revealed a beneficial impact of chronic resistance exercise (RE) on brain function. However, it is unclear as to whether RE is also effective in an acute setting.

Objective

To investigate the immediate effects of a single RE session on cognitive performance in healthy adults.

Methods

A multilevel meta-analysis with random effects meta-regression model was used to pool the standardized mean differences (SMD) between RE and no-exercise (NEX) as well as between RE and aerobic exercise (AE). In addition to global cognitive function, effects on reported sub-domains (inhibitory control, cognitive flexibility, working memory, attention) were examined.

Results

Twelve trials with fair methodological quality (PEDro scale) were identified. Compared to NEX, RE had a positive effect on global cognition (SMD: 0.56, 95% CI 0.22–0.90, p = 0.004), but was not superior to AE (SMD: − 0.10, 95% CI 0.01 to − 0.20, p = 0.06). Regarding cognitive sub-domains, RE, compared to NEX, improved inhibitory control (SMD: 0.73, 95% CI 0.21–1.26, p = 0.01) and cognitive flexibility (SMD: 0.36, 95% CI 0.17–0.55, p  = 0.004). In contrast, working memory (SMD: 0.35, 95% CI − 0.05 to 0.75, p  = 0.07) and attention (SMD: 0.79, 95% CI − 0.42 to 2.00, p = 0.16) remained unaffected. No significant differences in sub-domains were found between RE and AE (p > 0.05).

Conclusion

RE appears to be an appropriate method to immediately enhance cognitive function in healthy adults. Further studies clearly elucidating the impact of effect modifiers such as age, training intensity, or training duration are warranted.

Notes

Compliance with Ethical Standards

Funding

No sources of funding were used to assist in the preparation of this article.

Conflict of interest

Jan Wilke, Florian Giesche, Kristina Klier, Lutz Vogt, Eva Herrmann, and Winfried Banzer declare that they have no conflicts of interest relevant to the content of this review.

References

  1. 1.
    Löllgen H, Böckenhoff A, Knapp G. Physical activity and all-cause mortality: an updated meta-analysis with different intensity categories. Int J Sports Med. 2009;30:213–24.CrossRefGoogle Scholar
  2. 2.
    Vaynman S, Gomez-Pinilla F. License to run: exercise impacts functional plasticity in the intact and injured central nervous system by using neurotrophins. Neurorehabil Neural Repair. 2016;19:283–95.CrossRefGoogle Scholar
  3. 3.
    Thomas AG, Dennis A, Bandettini PA, et al. The effects of aerobic activity on brain structure. Front Psychol. 2012;3.Google Scholar
  4. 4.
    Liu PZ, Nusslock R. Exercise-mediated neurogenesis in the hippocampus via BDNF. Front Neurosci. 2018;12:450.Google Scholar
  5. 5.
    Kandola A, Hendrikse J, Lucassen PJ, et al. Aerobic exercise as a tool to improve hippocampal plasticity and function in humans: practical implications for mental health treatment. Front Hum Neurosci. 2016;10:373.CrossRefGoogle Scholar
  6. 6.
    Howland JG, Wang YT. Chapter 8 Synaptic plasticity in learning and memory: stress effects in the hippocampus. Essence of memory. Amsterdam: Elsevier; 2008. p. 145–58.Google Scholar
  7. 7.
    Colcombe S, Kramer AF. Fitness effects on the cognitive function of older adults. Psychol Sci. 2016;14:125–30.CrossRefGoogle Scholar
  8. 8.
    Smith PJ, Blumenthal JA, Hoffman BM, et al. Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom Med. 2010;72:239–52.CrossRefGoogle Scholar
  9. 9.
    Hindin SB, Zelinski EM. Extended practice and aerobic exercise interventions benefit untrained cognitive outcomes in older adults: a meta-analysis. J Am Geriatr Soc. 2012;60:136–41.CrossRefGoogle Scholar
  10. 10.
    McMorris T, Sproule J, Turner A, et al. Acute, intermediate intensity exercise, and speed and accuracy in working memory tasks: a meta-analytical comparison of effects. Physiol Behav. 2011;102:421–8.CrossRefGoogle Scholar
  11. 11.
    Chang Y, Labban J, Gapin J, et al. The effects of acute exercise on cognitive performance: a meta-analysis. Brain Res. 2012;1453:87–101.CrossRefGoogle Scholar
  12. 12.
    Ludyga S, Gerber M, Brand S, et al. Acute effects of moderate aerobic exercise on specific aspects of executive function in different age and fitness groups: a meta-analysis. Psychophysiology. 2016;53:1611–26.CrossRefGoogle Scholar
  13. 13.
    Groot C, Hooghiemstra A, Raijmakers P, et al. The effect of physical activity on cognitive function in patients with dementia: a meta-analysis of randomized control trials. Ageing Res Rev. 2016;25:13–23.CrossRefGoogle Scholar
  14. 14.
    Firth J, Stubbs B, Rosenbaum S, et al. Aerobic exercise improves cognitive functioning in people with schizophrenia: a systematic review and meta-analysis. Schizophr Bull. 2016;43:546–56.Google Scholar
  15. 15.
    Northey JM, Cherbuin N, Pumpa KL, et al. Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis. Br J Sports Med. 2018;52:154–60.CrossRefGoogle Scholar
  16. 16.
    de Greeff JW, Bosker RJ, Oosterlaan J, et al. Effects of physical activity on executive functions, attention and academic performance in preadolescent children: a meta-analysis. J Sci Med Sport. 2018;21:501–7.CrossRefGoogle Scholar
  17. 17.
    Song D, Yu DS, Li PW, et al. The effectiveness of physical exercise on cognitive and psychological outcomes in individuals with mild cognitive impairment: a systematic review and meta-analysis. Int J Nurs Stud. 2018;79:155–64.CrossRefGoogle Scholar
  18. 18.
    van Uffelen JGZ, Chin Paw MJM, Hopman-Rock M, et al. The effects of exercise on cognition in older adults with and without cognitive decline: a systematic review. Clin J Sport Med. 2008;18:486–500.CrossRefGoogle Scholar
  19. 19.
    Snowden M, Steinman L, Mochan K, et al. Effect of exercise on cognitive performance in community-dwelling older adults: review of intervention trials and recommendations for public health practice and research. J Am Geriatr Soc. 2011;59:704–16.CrossRefGoogle Scholar
  20. 20.
    Loprinzi PD, Frith E, Edwards MK. Resistance exercise and episodic memory function: a systematic review. Clin Physiol Funct Imaging. 2018;8:e76301.Google Scholar
  21. 21.
    Sáez de Asteasu ML, Martínez-Velilla N, Zambom-Ferraresi F, et al. Role of physical exercise on cognitive function in healthy older adults: a systematic review of randomized clinical trials. Ageing Res Rev. 2017;37:117–34.CrossRefGoogle Scholar
  22. 22.
    Kelly ME, Loughrey D, Lawlor BA, et al. The impact of exercise on the cognitive functioning of healthy older adults: a systematic review and meta-analysis. Ageing Res Rev. 2014;16:12–31.CrossRefGoogle Scholar
  23. 23.
    Sibley BA, Etnier JL. The relationship between physical activity and cognition in children: a meta-analysis. Pediatr Exerc Sci. 2003;15:243–56.CrossRefGoogle Scholar
  24. 24.
    Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535.CrossRefGoogle Scholar
  25. 25.
    Wager E, Wiffen PJ. Ethical issues in preparing and publishing systematic reviews. J Evid Based Med. 2011;4:130–4.CrossRefGoogle Scholar
  26. 26.
    Wilke J, Krause F, Vogt L, et al. What is evidence-based about myofascial chains: a systematic review. Arch Phys Med Rehabil. 2016;97:454–61.CrossRefGoogle Scholar
  27. 27.
    Krause F, Wilke J, Vogt L, et al. Intermuscular force transmission along myofascial chains: a systematic review. J Anat. 2016;228:910–8.CrossRefGoogle Scholar
  28. 28.
    Horsley T, Dingwall O, Sampson M. Checking reference lists to find additional studies for systematic reviews. Cochrane Database Syst Rev. 2011;73:505.Google Scholar
  29. 29.
    Maher CG, Sherrington C, Herbert RD, et al. Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther. 2003;83:713–21.Google Scholar
  30. 30.
    Foley CF, Bhogal SK, Teasell RW, et al. Estimates of quality and reliability with the physiotherapy evidence-based database scale to assess the methodology of randomized controlled trials of pharmacological and nonpharmacological interventions. Phys Ther. 2006;86(6):817–24.Google Scholar
  31. 31.
    de Morton NA. The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. Aust J Physiother. 2009;55:129–33.CrossRefGoogle Scholar
  32. 32.
    Rosenthal R. Meta-analytic procedures for social research. Newbury Park: Sage Publications; 1993.Google Scholar
  33. 33.
    Curtin F, Altman DG, Elbourne D. Meta-analysis combining parallel and cross-over clinical trials I: continuous outcomes. Stat Med. 2002;21:2131–44.CrossRefGoogle Scholar
  34. 34.
    Hedges LV, Tipton E, Johnson MC. Robust variance estimation in meta-regression with dependent effect size estimates. Res Synth Methods. 2010;1:39–65.CrossRefGoogle Scholar
  35. 35.
    Fisher Z, Tipton E. Robumeta. an r package for robust variance estimation in meta-analysis. https://arxiv.org/abs/1503.02220.
  36. 36.
    Radford JA, Burns J, Buchbinder R, et al. Does stretching increase ankle dorsiflexion range of motion? A systematic review. Br J Sports Med. 2006;40:870–5.CrossRefGoogle Scholar
  37. 37.
    Chang Y, Etnier JL. Effects of an acute bout of localized resistance exercise on cognitive performance in middle-aged adults: a randomized controlled trial study. Psychol Sport Exerc. 2009;10:19–24.CrossRefGoogle Scholar
  38. 38.
    Chang Y, Etnier JL. Exploring the dose-response relationship between resistance exercise intensity and cognitive function. J Sport Exerc Psychol. 2009;31:640–56.CrossRefGoogle Scholar
  39. 39.
    Pontifex MB, Hillman CH, Fernhall BO, et al. The effect of acute aerobic and resistance exercise on working memory. Med Sci Sports Exerc. 2009;41:927–34.CrossRefGoogle Scholar
  40. 40.
    Alves CRR, Gualano B, Takao PP, et al. Effects of acute physical exercise on executive functions: a comparison between aerobic and strength exercise. J Sport Exerc Psychol. 2012;34(4):539–49.CrossRefGoogle Scholar
  41. 41.
    Chang Y, Ku P, Tomporowski PD, et al. Effects of acute resistance exercise on late-middle-age adults’ goal planning. Med Sci Sports Exerc. 2012;44:1773–9.CrossRefGoogle Scholar
  42. 42.
    Chang Y, Tsai C, Huang C, et al. Effects of acute resistance exercise on cognition in late middle-aged adults: general or specific cognitive improvement? J Sci Med Sport. 2014;17:51–5.CrossRefGoogle Scholar
  43. 43.
    Tsai C, Wang C, Pan C, et al. Executive function and endocrinological responses to acute resistance exercise. Front Behav Neurosci. 2014;8:283.Google Scholar
  44. 44.
    Hsieh S, Chang Y, Hung T, et al. The effects of acute resistance exercise on young and older males’ working memory. Psychol Sport Exerc. 2016;22:286–93.CrossRefGoogle Scholar
  45. 45.
    Johnson L, Addamo PK, Selva Raj I, et al. An acute bout of exercise improves the cognitive performance of older adults. J Aging Phys Act. 2016;24:591–8.CrossRefGoogle Scholar
  46. 46.
    Chang H, Kim K, Jung Y, et al. Effects of acute high-intensity resistance exercise on cognitive function and oxygenation in prefrontal cortex. J Exerc Nutr Biochem. 2017;21(2):1–8.CrossRefGoogle Scholar
  47. 47.
    Dunsky A, Abu-Rukun M, Tsuk S, et al. The effects of a resistance vs an aerobic single session on attention and executive functioning in adults. PLoS One. 2017;12(4):0176092.CrossRefGoogle Scholar
  48. 48.
    Tsukamoto H, Suga T, Takenaka S, et al. An acute bout of localized resistance exercise can rapidly improve inhibitory control. PLoS One. 2017;12(9):e0184075.CrossRefGoogle Scholar
  49. 49.
    Querido JS, Sheel AW. Regulation of cerebral blood flow during exercise. Sports Med. 2007;37(9):765–82.CrossRefGoogle Scholar
  50. 50.
    Ogoh S, Ainslie PN. Cerebral blood flow during exercise: mechanisms of regulation. J Appl Physiol. 2009;107(5):1370–80.CrossRefGoogle Scholar
  51. 51.
    Yarrow JF, White LJ, McCoy SC, et al. Training augments resistance exercise induced elevation of circulating brain derived neurotrophic factor (BDNF). Neurosci Lett. 2010;479:161–5.CrossRefGoogle Scholar
  52. 52.
    Tsai C, Wang C, Pan C, et al. The effects of long-term resistance exercise on the relationship between neurocognitive performance and GH, IGF-1, and homocysteine levels in the elderly. Front Behav Neurosci. 2015;9:471.Google Scholar
  53. 53.
    Nieto-Estévez V, Defterali Ç, Vicario-Abejón C. IGF-I: a key growth factor that regulates neurogenesis and synaptogenesis from embryonic to adult stages of the brain. Front Neurosci. 2016;10:2896.CrossRefGoogle Scholar
  54. 54.
    Best JR, Chiu BK, Liang Hsu C, et al. Long-term effects of resistance exercise training on cognition and brain volume in older women: results from a randomized controlled trial. J Int Neuropsychol Soc. 2015;21:745–56.CrossRefGoogle Scholar
  55. 55.
    Grooms D, Appelbaum G, Onate J. Neuroplasticity following anterior cruciate ligament injury: a framework for visual-motor training approaches in rehabilitation. J Orthop Sports Phys Ther. 2015;45:381–93.CrossRefGoogle Scholar
  56. 56.
    Wilkerson GB. Neurocognitive reaction time predicts lower extremity sprains and strains. Int J Athl Ther Train. 2012;17:4–9.CrossRefGoogle Scholar
  57. 57.
    Huijgen BCH, Leemhuis S, Kok NM, et al. Cognitive functions in elite and sub-elite youth soccer players aged 13–17 years. PLoS One. 2015;10:e0144580.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Sports MedicineGoethe University FrankfurtFrankfurt/MainGermany
  2. 2.Institute of Biostatistics and Mathematical Modeling, Goethe University FrankfurtFrankfurt/MainGermany

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