Sports Medicine

, Volume 49, Issue 5, pp 823–825 | Cite as

Reply to Li et al.: Comment on “Effects of Carbohydrate Mouth Rinse on Cycling Time Trial Performance: A Systematic Review and Meta-Analysis”

  • Cayque Brietzke
  • Paulo Estevão Franco-Alvarenga
  • Flávio Oliveira PiresEmail author
Letter to the Editor

Dear Editor,

We thank Li et al. [1] for their comments on our recent systematic review and meta-analysis of the effects of carbohydrate (CHO) mouth rinse on cycling time trial performance [2]. In their letter, the authors pointed out that the different prandial state of participants in studies summarized in our review is a concern and warrants further discussion. They then reanalyzed the metadata, separating the reviewed studies into two subgroups—fasted and fed state—and concluded that a CHO mouth rinse may have an ergogenic benefit when exercise is performed in a fasted state but not in a fed state.

While we appreciate the debate and recommend further studies to investigate this issue, we were concerned with the analysis conducted by the authors to support their suggestion [ 1]. First, we agree that the prandial state of participants may have some effect on the ergogenic benefit when rinsing the mouth with CHO during exercise, and we considered this factor when planning our...


Compliance with Ethical Standards


No sources of funding were used to assist in the preparation of this letter.

Conflicts of interest

Cayque Brietzke, Paulo Estevão Franco-Alvarenga and Flávio Oliveira Pires declare that they have no conflicts of interest relevant to the content of this letter.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Exercise Psychophysiology Research Group, School of Arts, Sciences and HumanitiesUniversity of São PauloSão PauloBrazil

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