Sports Medicine

, Volume 49, Issue 2, pp 233–254 | Cite as

Does Aerobic Training Promote the Same Skeletal Muscle Hypertrophy as Resistance Training? A Systematic Review and Meta-Analysis

  • Jozo GrgicEmail author
  • Luke C. Mcllvenna
  • Jackson J. Fyfe
  • Filip Sabol
  • David J. Bishop
  • Brad J. Schoenfeld
  • Zeljko Pedisic
Systematic Review



Currently, there are inconsistencies in the body of evidence for the effects of resistance and aerobic training on skeletal muscle hypertrophy.


We aimed to systematically review and meta-analyze current evidence on the differences in hypertrophic adaptation to aerobic and resistance training, and to discuss potential reasons for the disparities noted in the literature.


The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed for this review. The Downs and Black checklist was used for the assessment of methodological quality of the included studies. A random-effects meta-analysis was employed. In total, three analyses were performed: (1) for whole-muscle knee extensor data; (2) for type I fiber cross-sectional area; and (3) for type II fiber cross-sectional area.


The final number of included studies in the present review is 21. All studies were of good or moderate methodological quality. The meta-analysis for whole-muscle hypertrophy resulted in a significant pooled difference (p < 0.001) in responses between the aerobic training and resistance training interventions. The pooled Hedge’s g, favoring resistance over aerobic training, was 0.66 (95% confidence interval 0.41–90; I2 = 0%). The meta-analysis for type I fiber cross-sectional area data resulted in a significant pooled difference (p < 0.001) between the aerobic training and resistance training groups. The pooled Hedge’s g, favoring resistance training over aerobic training, was 0.99 (95% confidence interval 0.44–1.54; I2 = 24%). The meta-analysis of type II fiber cross-sectional area data resulted in a significant pooled difference (p < 0.001) between the aerobic training and resistance training groups. The pooled Hedge’s g, favoring resistance training over aerobic training, was 1.44 (95% confidence interval 0.93–1.95; I2 = 8%).


The results of this systematic review and meta-analysis suggest that single-mode aerobic training does not promote the same skeletal muscle hypertrophy as resistance training. This finding was consistent with measurements of muscle hypertrophy both at the whole-muscle and myofiber levels. While these results are specific to the knee extensor musculature, it can be hypothesized that similar results would be seen for other muscle groups as well.


Compliance with Ethical Standards


No external sources of funding were used to assist in the preparation of this article.

Conflict of interest

Jozo Grgic, Luke C. Mcllvenna, Jackson J. Fyfe, Filip Sabol, David J. Bishop, Brad J. Schoenfeld, and Zeljko Pedisic have no conflicts of interest that are directly relevant to the contents of this review.

Supplementary material

40279_2018_1008_MOESM1_ESM.docx (21 kb)
Supplementary material 1 (DOCX 20 kb)


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Jozo Grgic
    • 1
    Email author
  • Luke C. Mcllvenna
    • 1
  • Jackson J. Fyfe
    • 2
    • 3
  • Filip Sabol
    • 4
    • 5
  • David J. Bishop
    • 1
    • 6
  • Brad J. Schoenfeld
    • 7
  • Zeljko Pedisic
    • 1
  1. 1.Institute for Health and Sport (IHES)Victoria UniversityMelbourneAustralia
  2. 2.School of Exercise and Nutrition SciencesDeakin University, BurwoodMelbourneAustralia
  3. 3.Centre for Sport ResearchDeakin University, BurwoodMelbourneAustralia
  4. 4.Fitness AcademyZagrebCroatia
  5. 5.Faculty of KinesiologyUniversity of ZagrebZagrebCroatia
  6. 6.School of Medical and Health SciencesEdith Cowan UniversityJoondalupAustralia
  7. 7.Department of Health SciencesLehman CollegeBronxUSA

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