Polyphenols and Performance: A Systematic Review and Meta-Analysis
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Polyphenols exert physiological effects that may impact athletic performance. Polyphenols are antioxidants that have been noted to hinder training adaptations, yet conversely they stimulate stress-related cell signalling pathways that trigger mitochondrial biogenesis and influence vascular function.
To determine the overall effect of polyphenols on human athletic performance.
A search strategy was completed using MEDLINE, EMBASE, CINAHL, AMED and SPORTDiscus in April 2016. The studies were screened and independently reviewed by two researchers against predetermined criteria for eligibility. As a result of this screening, 14 studies were included for meta-analysis. Of these, the studied populations were predominately-trained males with an average intervention dose of 688 ± 478 mg·day−1.
The pooled results demonstrate polyphenol supplementation for at least 7 days increases performance by 1.90% (95% CI 0.40–3.39). Sub-analysis of seven studies using quercetin identified a performance increase of 2.82% (95% CI 2.05–3.58). There were no adverse effects reported in the studies in relation to the intervention.
Overall the pooled results show that polyphenols, and of note quercetin, are viable supplements to improve performance in healthy individuals.
KeywordsQuercetin Polyphenol Resveratrol Mitochondrial Biogenesis Athletic Performance
VS and AB conceived and designed the study; VS and CB performed the literature search and were responsible for decisions on inclusion/exclusion of articles (with AB as the decider if there was disagreement); VS analysed the data; VS and AB wrote the article.
Compliance with Ethical Standards
No sources of funding were used to assist in the preparation of this article.
Conflict of interest
Vaughan Somerville, Cameron Bringans and Andrea Braakhuis declare that they have no conflicts of interest relevant to the content of this review.
- 11.Gomez-Cabrera MC, Ristow M, Vina J. Antioxidant supplements in exercise: worse than useless? Am J Physiol Endocrinol Metab. 2012;302(4):E476,7 (author reply E478–9).Google Scholar
- 12.Gomez-Cabrera MC, Salvador-Pascual A, Cabo H, et al. Redox modulation of mitochondriogenesis in exercise. Does antioxidant supplementation blunt the benefits of exercise training? Free Radic Biol Med. 2015;86:37–46.Google Scholar
- 14.Visioli F. Polyphenols in sport: facts or fads? In: Lamprecht M, editor. Boca Raton: Taylor & Francis Group, LLC; 2015.Google Scholar
- 15.Stevenson DE. Polyphenols as adaptogens–the real mechanism of the antioxidant effect? In: Anonymous. Croatia: InTech Rijeka; 2012. p. 143–62.Google Scholar
- 30.McArdle WD, Katch FI, Katch VL. Essentials of exercise physiology. Philadelphia: Lippincott Williams & Wilkins; 2006.Google Scholar
- 38.Hopkins WG. A spreadsheet for deriving a confidence interval, mechanistic inference and clinical inference from a P value. Sportscience. 2007;11:16–21.Google Scholar
- 43.Cureton KJ, Tomporowski PD, Singhal A, et al. Dietary quercetin supplementation is not ergogenic in untrained men. J Appl Physiol (1985). 2009;107(4):1095–104.Google Scholar
- 44.Davis JM, Carlstedt CJ, Chen S, et al. The dietary flavonoid quercetin increases VO2max and endurance capacity. Int J Sport Nutr. 2010;20(1):56–62.Google Scholar
- 60.Rothwell JA, Perez-Jimenez J, Neveu V, et al. Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content. Database (Oxford). 2013;2013:bat070.Google Scholar