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Sports Medicine

, Volume 46, Issue 5, pp 629–639 | Cite as

Role of Exercise-Induced Oxidative Stress in Sickle Cell Trait and Disease

  • Erica N. Chirico
  • Camille Faës
  • Philippe Connes
  • Emmanuelle Canet-Soulas
  • Cyril Martin
  • Vincent Pialoux
Review Article

Abstract

Sickle cell disease is a class of hemoglobinopathy in humans, which is the most common inherited disease in the world. Although complications of sickle cell disease start from polymerization of red blood cells during its deoxygenating phase, the oxidative stress resulting from the biological processes associated with this disease (ischaemic and hypoxic injuries, hemolysis and inflammation) has been shown to contribute to its pathophysiology. It is widely known that chronic exercise reduces oxidative stress in healthy people, mainly via improvement of antioxidant enzyme efficiency. In addition, recent studies in other diseases, as well as in sickle cell trait carriers and in a mouse model of sickle cell disease, have shown that regular physical activity could decrease oxidative stress. The purpose of this review is to summarize the role of oxidative stress in sickle cell disease and the effects of acute and chronic exercise on the pro-oxidant/antioxidant balance in sickle cell trait and sickle cell disease.

Keywords

Nitric Oxide Exercise Training Sickle Cell Disease Xanthine Oxidase Sickle Cell Trait 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Compliance with Ethical Standards

Conflicts of interest

Erica Chirico, Camille Faës, Philippe Connes, Emmanuelle Canet-Soulas, Cyril Martin and Vincent Pialoux declare that they have no conflicts of interest that are relevant to the content of this review.

Funding

No sources of funding were used in the preparation of this review.

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Erica N. Chirico
    • 1
    • 2
  • Camille Faës
    • 1
    • 3
  • Philippe Connes
    • 1
    • 3
    • 4
  • Emmanuelle Canet-Soulas
    • 2
  • Cyril Martin
    • 1
    • 3
  • Vincent Pialoux
    • 1
    • 3
    • 4
  1. 1.EA 647 Centre de Recherche et d’Innovation sur le SportUniversité Claude Bernard Lyon 1, Université de LyonVilleurbanneFrance
  2. 2.Cardiovascular, Metabolism, Diabetes, and Nutrition (CarMeN INSERM U-1060), Faculty of Medicine Lyon SudUniversité Claude Bernard Lyon 1OullinsFrance
  3. 3.Laboratory of Excellence in Red Blood Cell (LABEX GR-Ex)PRES SorbonneParisFrance
  4. 4.Institut Universitaire de FranceParisFrance

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