Creatine Supplementation and Lower Limb Strength Performance: A Systematic Review and Meta-Analyses
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Creatine is the most widely used supplementation to increase strength performance. However, the few meta-analyses are more than 10 years old and suffer from inclusion bias such as the absence of randomization and placebo, the diversity of the inclusion criteria (aerobic/endurance, anaerobic/strength), no evaluation on specific muscles or group of muscles, and the considerable amount of conflicting results within the last decade.
The objective of this systematic review was to evaluate meta-analyzed effects of creatine supplementation on lower limb strength performance.
We conducted a systematic review and meta-analyses of all randomized controlled trials comparing creatine supplementation with a placebo, with strength performance of the lower limbs measured in exercises lasting less than 3 min. The search strategy used the keywords “creatine supplementation” and “performance”. Dependent variables were creatine loading, total dose, duration, the time-intervals between baseline (T0) and the end of the supplementation (T1), as well as any training during supplementation. Independent variables were age, sex, and level of physical activity at baseline. We conducted meta-analyses at T1, and on changes between T0 and T1. Each meta-analysis was stratified within lower limb muscle groups and exercise tests.
We included 60 studies (646 individuals in the creatine supplementation group and 651 controls). At T1, the effect size (ES) among stratification for squat and leg press were, respectively, 0.336 (95 % CI 0.047–0.625, p = 0.023) and 0.297 (95 % CI 0.098–0.496, p = 0.003). Overall quadriceps ES was 0.266 (95 % CI 0.150–0.381, p < 0.001). Global lower limb ES was 0.235 (95 % CI 0.125–0.346, p < 0.001). Meta-analysis on changes between T0 and T1 gave similar results. The meta-regression showed no links with characteristics of population or of supplementation, demonstrating the creatine efficacy effects, independent of all listed conditions.
Creatine supplementation is effective in lower limb strength performance for exercise with a duration of less than 3 min, independent of population characteristic, training protocols, and supplementary doses and duration.
- 10.Ayoama R, Hiruma E, Sasaki H. Effects of creatine loading on muscular strength and endurance of female softball players. J Sports Med Phys Fit. 2003;43(4):481–7.Google Scholar
- 12.Brenner M, Walberg Rankin J, Sebolt D. The effect of creatine supplementation during resistance training in women. J Strength Cond Res. 2000;14(2):207–13.Google Scholar
- 15.Larson-Meyer DE, Hunter GR, Trowbridge CA, et al. The effect of creatine supplementation on muscle strength and body composition during off-season training in female soccer players. J Strength Cond Res. 2000;14(4):434–42.Google Scholar
- 16.Vandenberghe K, Goris M, Van Hecke P, et al. Long-term creatine intake is beneficial to muscle performance during resistance training. J Appl Physiol. 1985;83(6):2055–63.Google Scholar
- 31.Kirksey B, Stone MH, Warren BJ, et al. The effects of 6 weeks of creatine monohydrate supplementation on performance measures and body composition in collegiate track and field athletes. J Strength Cond Res. 1999;13(2):148–56.Google Scholar
- 33.Cornish SM, Chilibeck PD, Burke DG. The effect of creatine monohydrate supplementation on sprint skating in ice-hockey players. J Sports Med Phys Fit. 2006;46(1):90–8.Google Scholar
- 39.Syrotuik DG, Bell GJ, Burnham R, et al. Absolute and relative strength performance following creatine monohydrate supplementation combined with periodized resistance training. J Strength Cond Res. 2000;14(2):182–90.Google Scholar
- 45.Hutton J, Cochrane T. Influence of creatine supplementation on performance in sprint athletes. Sports Exerc Injury. 1998;4(4):199–203.Google Scholar
- 64.Bogdanis GC, Nevill ME, Lakomy HKA, et al. The effects of oral creatine supplementation on power output during repeated treadmill sprinting. J Sports Sci. 1996;14(1):65–6.Google Scholar