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Sports Medicine

, Volume 44, Issue 11, pp 1557–1572 | Cite as

Association between Physical Activity Advice Only or Structured Exercise Training with Blood Pressure Levels in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis

  • Franciele R. Figueira
  • Daniel Umpierre
  • Felipe V. Cureau
  • Alessandra T. N. Zucatti
  • Mériane B. Dalzochio
  • Cristiane B. Leitão
  • Beatriz D. Schaan
Systematic Review

Abstract

Background

Diabetes is associated with marked cardiovascular morbidity and mortality. However, the association between different types of exercise training and blood pressure (BP) changes is not fully clear in type 2 diabetes.

Objective

The aim of this systematic review and meta-analysis of randomized controlled clinical trials (RCTs) was to determine the effects of structured exercise training (aerobic [AER], resistance [RES], or combined [COMB]) and physical activity (PA) advice only on BP changes in patients with type 2 diabetes.

Methods

Searches in five electronic databases were conducted to retrieve studies published from 1980 to 2013. Eligible studies were RCTs consisting of structured exercise training or PA advice versus no intervention in patients with type 2 diabetes. We used random effect models to derive weighted mean differences (WMDs) of exercises on absolute changes in systolic BP (SBP) and diastolic BP (DBP).

Results

A total of 30 RCTs of structured training (2,217 patients) and 21 of PA advice (7,323 patients) were included. Data were extracted independently in duplicate. Structured exercise was associated with reductions in SBP (WMD −4.22 mmHg; 95 % confidence interval [CI] −5.89 to −2.56) and DBP (WMD −2.07 mmHg; 95 % CI −3.03 to −1.11) versus controls. In structured exercise interventions, AER and RES were associated with declines in BP, and COMB was not associated with BP changes. However, in sensitivity analysis, a high-intensity protocol within COMB was associated with declines in SBP (WMD −3.30 mmHg; 95 % CI −4.71 to −1.89). Structured exercise longer than 150 min/week was associated with greater BP reductions. PA advice only was associated with reduction in SBP (WMD −2.97 mmHg; 95 % CI −4.52 to −1.43) and DBP (WMD −1.41 mmHg; 95 % CI −1.94 to −0.88) versus controls.

Conclusions

AER, RES, and high-intensity combined training are associated with BP reduction in patients with type 2 diabetes, especially in exercise programs lasting more than 150 min/week. PA advice only is also associated with lower BP levels.

Keywords

Exercise Training Resistance Training Blood Pressure Reduction Aerobic Exercise Training Electronic Supplementary Material Figure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Mrs. Figueira had full access to the data and takes full responsibility for its integrity.

Conception and design: Schaan, Leitão, Umpierre. Data search: Schaan, Leitão, Umpierre, Figueira, Zucatti. Analysis and interpretation of data: Schaan, Leitão, Umpierre, Figueira, Cureau, Dalzochio. Drafting of the manuscript: Schaan, Leitão, Umpierre, Figueira, Cureau. Revising the manuscript critically for important intellectual content: Schaan, Leitão, Umpierre, Figueira, Cureau. Final approval of the manuscript submitted: Schaan, Leitão, Umpierre, Figueira, Cureau, Zucatti, Dalzochio.

Funding for this manuscript was partially provided by Fundo de Incentivo à Pesquisa do HCPA (FIPE), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, PNPD 2818/2011).

Role of funding source: the sponsor of the manuscript had no role in the design of the review and meta-analysis, data collection, data analysis, data interpretation, or writing of the report.

All authors have no conflicts of interest to declare.

Supplementary material

40279_2014_226_MOESM1_ESM.doc (532 kb)
Supplementary material 1 (DOC 533 kb)

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Franciele R. Figueira
    • 1
    • 2
  • Daniel Umpierre
    • 1
    • 3
  • Felipe V. Cureau
    • 2
  • Alessandra T. N. Zucatti
    • 2
  • Mériane B. Dalzochio
    • 1
  • Cristiane B. Leitão
    • 2
  • Beatriz D. Schaan
    • 2
    • 3
    • 4
    • 5
  1. 1.Exercise Pathophysiology Research LaboratoryHospital de Clinicas de Porto AlegrePorto AlegreBrazil
  2. 2.Postgraduate Program in Health Sciences: EndocrinologyUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  3. 3.Postgraduate Program in Health Sciences, Cardiovascular SciencesUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  4. 4.Endocrine Division, Serviço de Endocrinologia, Hospital de Clínicas de Porto AlegrePorto AlegreBrazil
  5. 5.Department of Internal Medicine, Faculty of MedicineUniversidade Federal do Rio Grande do SulPorto AlegreBrazil

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