Acute Exercise and Hormones Related to Appetite Regulation: A Meta-Analysis
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Understanding of the impact of an acute bout of exercise on hormones involved in appetite regulation may provide insight into some of the mechanisms that regulate energy balance. In resting conditions, acylated ghrelin is known to stimulate food intake, while hormones such as peptide YY (PYY), pancreatic polypeptide (PP) and glucagon-like peptide 1 (GLP-1) are known to suppress food intake.
The objective of this review was to determine the magnitude of exercise effects on levels of gastrointestinal hormones related to appetite, using systematic review and meta-analysis. Additionally, factors such as the exercise intensity, duration and mode, in addition to participant characteristics, were examined to determine their influence on these hormones.
Major databases (PubMed, Scopus, Google Scholar, Science Direct, Academic Search Premier and EBSCOHost) were searched, through February 2013, for original studies, abstracts, theses and dissertations that examined responses of appetite hormones to acute exercise.
Studies were included if they evaluated appetite hormone responses during and in the hours after an acute bout of exercise and reported area under the concentration–time curve (AUC) values for more than three datapoints. Studies reporting mean or pre/post-values only were excluded.
Study Appraisal and Synthesis
Initially, 75 studies were identified. After evaluation of study quality and validity, using the Physiotherapy Evidence Database scale, data from 20 studies (28 trials) involving 241 participants (77.6 % men) had their data extracted for inclusion in the meta-analyses. A random-effects meta-analysis was conducted for acylated ghrelin (n = 18 studies, 25 trials) and PYY (n = 8 studies, 14 trials), with sub-group analyses and meta-regressions being conducted for moderator variables. Because the number of studies was limited, fixed-effects meta-analyses were performed on PP data (n = 4 studies, 5 trials) and GLP-1 data (n = 5 studies, 8 trials).
The results of the meta-analyses indicated that exercise had small to moderate effects on appetite hormone levels, suppressing acylated ghrelin (effect size [ES] Cohen’s d value −0.20, 95 % confidence interval [CI] −0.373 to −0.027; median decrease 16.5 %) and increasing PYY (ES 0.24, 95 % CI 0.007 to 0.475; median increase 8.9 %), GLP-1 (ES 0.275, 95 % CI −0.031 to 0.581; median increase 13 %), and PP (ES 0.50, 95 % CI 0.11 to 0.89; median increase 15 %). No significant heterogeneity was detected in any meta-analysis (using Cochrane’s Q and I 2); however, publication biases were detected for all analyses. No moderator variables were observed to moderate the variability among the studies assessing acylated ghrelin and PYY.
The majority of the present literature is acute in nature; therefore, longer-term alterations in appetite hormone concentrations and their influence on food and beverage intake are unknown. Furthermore, our review was limited to English-language studies and studies reporting AUC data.
An acute bout of exercise may influence appetite by suppressing levels of acylated ghrelin while simultaneously increasing levels of PYY, GLP-1 and PP, which may contribute to alterations in food and drink intake after acute exercise. Further longitudinal studies and exploration into mechanisms of action are required in order to determine the precise role these hormones play in long-term appetite responses to an exercise intervention.
KeywordsExercise Bout Acute Exercise Pancreatic Polypeptide Ghrelin Concentration Acute Bout
The authors declare no conflict of interest. No funding was obtained for this review. The authors would like to express extreme gratitude to several authors cited herein for providing access to data. The authors would also like to thank the peer reviewers for their constructive comments, which improved the manuscript.
- 22.King JA, Wasse LK, Ewens J, Crystallis K, Emmanuel J, Batterham RL, et al. Differential acylated ghrelin, peptide YY3-36, appetite, and food intake responses to equivalent energy deficits created by exercise and food restriction. J Clin Endocrinol Metab. 2011;96(4):1114–21. doi: 10.1210/jc.2010-2735.PubMedCrossRefGoogle Scholar
- 23.King JA, Wasse LK, Stensel DJ. The acute effects of swimming on appetite, food intake, and plasma acylated ghrelin. J Obes. 2011;2011(Article ID 351628):1–8. doi: 10.1155/2011/351628.
- 30.Gibbons C, Caudwell P, Finlayson G, Webb DL, Hellstrom PM, Naslund E, et al. Comparison of postprandial profiles of ghrelin, active GLP-1, and total PYY to meals varying in fat and carbohydrate and their association with hunger and the phases of satiety. J Clin Endocrinol Metab. 2013;98(5):E847–55. doi: 10.1210/jc.2012-3835.PubMedCrossRefGoogle Scholar
- 32.Larson-Meyer DE, Palm S, Bansal A, Austin KJ, Hart AM, Alexander BM. Influence of running and walking on hormonal regulators of appetite in women. J Obes. 2012;2012(Article ID 730409):1–15. doi: 10.1155/2012/730409.
- 33.King JA, Wasse LK, Stensel DJ. The acute effects of swimming on appetite, food intake, and plasma acylated ghrelin. J Obes. 2011;2011. doi: 10.1155/2011/351628.
- 36.Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009;6(7):e1000100. doi: 10.1371/journal.pmed.1000100.PubMedCentralPubMedCrossRefGoogle Scholar
- 39.Wasse LK, Sunderland C, King JA, Batterham RL, Stensel DJ. Influence of rest and exercise at a simulated altitude of 4,000 m on appetite, energy intake, and plasma concentrations of acylated ghrelin and peptide YY. J Appl Physiol. 2012;112(4):552–9. doi: 10.1152/japplphysiol.00090.2011.PubMedCrossRefGoogle Scholar
- 41.PEDro Scale. http://www.pedro.org.au. Accessed 15 July 2012.
- 42.Wood JM. Understanding and computing Cohen’s kappa: a tutorial. Web Psych Empiricist 2007.Google Scholar
- 56.Donnelly JE, Hill JO, Jacobsen DJ, Potteiger J, Sullivan DK, Johnson SL, et al. Effects of a 16-month randomized controlled exercise trial on body weight and composition in young, overweight men and women: the Midwest Exercise Trial. Arch Intern Med. 2003;163(11):1343–50. doi: 10.1001/archinte.163.11.1343.PubMedCrossRefGoogle Scholar
- 62.Madsbad S. The role of glucagon-like peptide-1 impairment in obesity and potential therapeutic implications. Diabetes Obes Metab. 2013. doi: 10.1111/dom.12119.
- 64.Glaros NM, Janelle CM. Varying the mode of cardiovascular exercise to increase adherence. J Sport Behav. 2001;24(1):42–62.Google Scholar
- 66.Vatansever-Ozen S, Tiryaki-Sonmez G, Bugdayci G, Ozen G. The effects of exercise on food intake and hunger: relationship with acylated ghrelin and leptin. J Sport Sci Med. 2011;10:283–91.Google Scholar
- 69.Finlayson G, Caudwell P, Gibbons C, Hopkins M, King N, Blundell J. Low fat loss response after medium-term supervised exercise in obese is associated with exercise-induced increase in food reward. J Obes. 2011;2011. doi: 10.1155/2011/615624.
- 70.Hopkins M, Blundell JE, King NA. Individual variability in compensatory eating following acute exercise in overweight and obese women. Br J Sports Med. 2013. doi: 10.1136/bjsports-2012-091721.
- 71.Caudwell P, Finlayson G, Gibbons C, Hopkins M, King N, Naslund E, et al. Resting metabolic rate is associated with hunger, self-determined meal size, and daily energy intake and may represent a marker for appetite. Am J Clin Nutr. 2013;97(1):7–14. doi: 10.3945/ajcn.111.029975.PubMedCrossRefGoogle Scholar
- 76.Foster-Schubert KE, Overduin J, Prudom CE, Liu J, Callahan HS, Gaylinn BD, et al. Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydrates. J Clin Endocrinol Metab. 2008;93(5):1971–9. doi: 10.1210/jc.2007-2289.PubMedCrossRefGoogle Scholar