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Sports Medicine

, Volume 43, Issue 6, pp 483–512 | Cite as

Eccentric Exercise Training: Modalities, Applications and Perspectives

  • Marie-Eve Isner-Horobeti
  • Stéphane Pascal Dufour
  • Philippe Vautravers
  • Bernard Geny
  • Emmanuel Coudeyre
  • Ruddy Richard
Review Article

Abstract

Eccentric (ECC) exercise is classically used to improve muscle strength and power in healthy subjects and athletes. Due to its specific physiological and mechanical properties, there is an increasing interest in employing ECC muscle work for rehabilitation and clinical purposes. Nowadays, ECC muscle actions can be generated using various exercise modalities that target small or large muscle masses with minimal or no muscle damage or pain. The most interesting feature of ECC muscle actions is to combine high muscle force with a low energy cost (typically 4- to 5-times lower than concentric muscle work) when measured during leg cycle ergometry at a similar mechanical power output. Therefore, if caution is taken to minimize the occurrence of muscle damage, ECC muscle exercise can be proposed not only to athletes and healthy subjects, but also to individuals with moderately to severely limited exercise capacity, with the ultimate goal being to improve their functional capacity and quality of life. The first part of this review article describes the available exercise modalities to generate ECC muscle work, including strength and conditioning exercises using the body’s weight and/or additional external loads, classical isotonic or isokinetic exercises and, in addition, the oldest and newest specifically designed ECC ergometers. The second part highlights the physiological and mechanical properties of ECC muscle actions, such as the well-known higher muscle force-generating capacity and also the often overlooked specific cardiovascular and metabolic responses. This point is particularly emphasized by comparing ECC and concentric muscle work performed at similar mechanical (i.e., cycling mechanical power) or metabolic power (i.e., oxygen uptake, \( \dot{V}{\text{O}}_{2} \)). In particular, at a similar mechanical power, ECC muscle work induces lower metabolic and cardiovascular responses than concentric muscle work. However, when both exercise modes are performed at a similar level of \( \dot{V}{\text{O}}_{2} \), a greater cardiovascular stress is observed during ECC muscle work. This observation underlines the need of cautious interpretation of the heart rate values for training load management because the same training heart rate actually elicits a lower \( \dot{V}{\text{O}}_{2} \) in ECC muscle work than in concentric muscle work. The last part of this article reviews the documented applications of ECC exercise training and, when possible, presents information on single-joint movement training and cycling or running training programs, respectively. The available knowledge is then summarized according to the specific training objectives including performance improvement for healthy subjects and athletes, and prevention of and/or rehabilitation after injury. The final part of the article also details the current knowledge on the effects of ECC exercise training in elderly populations and in patients with chronic cardiac, respiratory, metabolic or neurological disease, as well as cancer. In conclusion, ECC exercise is a promising training modality with many different domains of application. However, more research work is needed to better understand how the neuromuscular system adapts to ECC exercise training in order to optimize and better individualize future ECC training strategies.

Keywords

Muscle Work Functional Capacity Index Traditional Resistance Training Nordic Hamstring Exercise Delay Onset Muscular Soreness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors would like to thank all the laboratory staff of the Physiology and Functional Explorations Department and the Equipe d’Accueil 3072. The help of Drs. Evelyne Lonsdorfer-Wolf, Laurence Rasseneur and Stéphane Doutreleau and of Prof. Fabrice Favret in the development of research on the acute and chronic effects of ECC muscle work in our team is acknowledged and greatly appreciated. The authors have no conflicts of interest that are directly relevant to the content of this article.

References

  1. 1.
    Armstrong RB. Mechanisms of exercise-induced delayed onset muscular soreness: a brief review. Med Sci Sports Exerc. 1984;16(6):529–38.PubMedGoogle Scholar
  2. 2.
    Lieber RL, Friden J. Morphologic and mechanical basis of delayed-onset muscle soreness. J Am Acad Orthop Surg. 2002;10(1):67–73.Google Scholar
  3. 3.
    Cheung K, Hume P, Maxwell L. Delayed onset muscle soreness: treatment strategies and performance factors. Sports Med. 2003;33(2):145–64.PubMedCrossRefGoogle Scholar
  4. 4.
    LaStayo PC, Woolf JM, Lewek MD, et al. Eccentric muscle contractions: their contribution to injury, prevention, rehabilitation, and sport. J Orthop Sports Phys Ther. 2003;33(10):557–71.PubMedGoogle Scholar
  5. 5.
    Lindstedt SL, LaStayo PC, Reich TE. When active muscles lengthen: properties and consequences of eccentric contractions. News Physiol Sci. 2001;16:256–61.PubMedGoogle Scholar
  6. 6.
    Chauveau A. La loi de l’équivalence dans les transformations de la force chez les animaux. C R Acad Sci. 122. 1896:113–20.Google Scholar
  7. 7.
    Stanish WD, Rubinovich RM, Curwin S. Eccentric exercise in chronic tendinitis. Clin Orthop Relat Res. 1986;208:65–8.PubMedGoogle Scholar
  8. 8.
    Fyfe I, Stanish WD. The use of eccentric training and stretching in the treatment and prevention of tendon injuries. Clin Sports Med. 1992;11(3):601–24.PubMedGoogle Scholar
  9. 9.
    Jonhagen S, Ackermann P, Saartok T. Forward lunge: a training study of eccentric exercises of the lower limbs. J Strength Cond Res. 2009;23(3):972–8.PubMedCrossRefGoogle Scholar
  10. 10.
    Arnason A, Andersen TE, Holme I, Engebretsen L, Bahr R. Prevention of hamstring strains in elite soccer: an intervention study. Scand J Med Sci Sports. 2008;18(1):40–8.PubMedCrossRefGoogle Scholar
  11. 11.
    Kellis E, Baltzopoulos V. Isokinetic eccentric exercise. Sports Med. 1995;19(3):202–22.PubMedCrossRefGoogle Scholar
  12. 12.
    Abbott BC, Bigland B, Ritchie JM. The physiological cost of negative work. J Physiol. 1952;117(3):380–90.PubMedGoogle Scholar
  13. 13.
    Abbott BC, Bigland B. The effects of force and speed changes on the rate of oxygen consumption during negative work. J Physiol. 1953;120(3):319–25.PubMedGoogle Scholar
  14. 14.
    Dufour SP, Lampert E, Doutreleau S, et al. Eccentric cycle exercise: training application of specific circulatory adjustments. Med Sci Sports Exerc. 2004;36(11):1900–6.PubMedCrossRefGoogle Scholar
  15. 15.
    Elmer SJ, Madigan ML, LaStayo PC, et al. Joint-specific power absorption during eccentric cycling. Clin Biomech (Bristol, Avon). 2010;25(2):154–8.Google Scholar
  16. 16.
    Marcus RL, Smith S, Morrell G, et al. Comparison of combined aerobic and high-force eccentric resistance exercise with aerobic exercise only for people with type 2 diabetes mellitus. Phys Ther. 2008;88(11):1345–54.PubMedCrossRefGoogle Scholar
  17. 17.
    Lastayo PC, Larsen S, Smith S, et al. The feasibility and efficacy of eccentric exercise with older cancer survivors: a preliminary study. J Geriatr Phys Ther. 2010;33(3):135–40.Google Scholar
  18. 18.
    Elmer SJ, Danvind J, Holmberg HC. Development of a novel eccentric arm cycle ergometer for training the upper body. Med Sci Sports Exerc. Epub 2012 Jul 26.Google Scholar
  19. 19.
    Cavanagh PR, Komi PV. Electromechanical delay in human skeletal muscle under concentric and eccentric contractions. Eur J Appl Physiol Occup Physiol. 1979;42(3):159–63.PubMedCrossRefGoogle Scholar
  20. 20.
    Faulkner JA. Terminology for contractions of muscles during shortening, while isometric, and during lengthening. J Appl Physiol. 2003;95(2):455–9.PubMedGoogle Scholar
  21. 21.
    Westing SH, Seger JY. Eccentric and concentric torque-velocity characteristics, torque output comparisons, and gravity effect torque corrections for the quadriceps and hamstring muscles in females. Int J Sports Med. 1989;10(3):175–80.PubMedCrossRefGoogle Scholar
  22. 22.
    Westing SH, Cresswell AG, Thorstensson A. Muscle activation during maximal voluntary eccentric and concentric knee extension. Eur J Appl Physiol Occup Physiol. 1991;62(2):104–8.PubMedCrossRefGoogle Scholar
  23. 23.
    Crenshaw AG, Karlsson S, Styf J, et al. Knee extension torque and intramuscular pressure of the vastus lateralis muscle during eccentric and concentric activities. Eur J Appl Physiol Occup Physiol. 1995;70(1):13–9.PubMedCrossRefGoogle Scholar
  24. 24.
    Brunelli S, Sciorati C, D’Antona G, et al. Nitric oxide release combined with nonsteroidal antiinflammatory activity prevents muscular dystrophy pathology and enhances stem cell therapy. Proc Natl Acad Sci USA. 2007;104(1):264–9.PubMedCrossRefGoogle Scholar
  25. 25.
    Enoka RM. Eccentric contractions require unique activation strategies by the nervous system. J Appl Physiol. 1996;81(6):2339–46.PubMedGoogle Scholar
  26. 26.
    Katz B. The relation between force and speed in muscular contraction. J Physiol. 1939;96:45–64.PubMedGoogle Scholar
  27. 27.
    Hill AV. The heat of shortening and the dynamics constants of muscle. Proc R Soc Lond B Biol Sci. 1938;126:136–95.CrossRefGoogle Scholar
  28. 28.
    Westing SH, Seger JY, Karlson E. Eccentric and concentric torque-velocity characteristics of the quadriceps femoris in man. Eur J Appl Physiol Occup Physiol. 1988;58(1–2):100–4.PubMedCrossRefGoogle Scholar
  29. 29.
    Mayer F, Horstmann T, Rocker K, et al. Normal values of isokinetic maximum strength, the strength/velocity curve, and the angle at peak torque of all degrees of freedom in the shoulder. Int J Sports Med. 1994;15(Suppl. 1):S19–25.PubMedCrossRefGoogle Scholar
  30. 30.
    Roig M, O’Brien K, Kirk G, et al. The effects of eccentric versus concentric resistance training on muscle strength and mass in healthy adults: a systematic review with meta-analysis. Br J Sports Med. 2009;43(8):556–68.PubMedCrossRefGoogle Scholar
  31. 31.
    Fang Y, Siemionow V, Sahgal V, Xiong F, Yue GH. Distinct brain activation patterns for human maximal voluntary eccentric and concentric muscle actions. Brain Res. 2004;1023(2):200–12.PubMedCrossRefGoogle Scholar
  32. 32.
    McHugh MP, Tyler TF, Greenberg SC, et al. Differences in activation patterns between eccentric and concentric quadriceps contractions. J Sports Sci. 2002;20(2):83–91.PubMedCrossRefGoogle Scholar
  33. 33.
    Bigland-Ritchie B, Woods JJ. Integrated electromyogram and oxygen uptake during positive and negative work. J Physiol. 1976;260(2):267–77.PubMedGoogle Scholar
  34. 34.
    Perrey S, Betik A, Candau R, et al. Comparison of oxygen uptake kinetics during concentric and eccentric cycle exercise. J Appl Physiol. 2001;91(5):2135–42.PubMedGoogle Scholar
  35. 35.
    Navalta JW. Physiological responses to downhill walking in older and younger individuals. J Exer Physiol. 2004;7(6):45–51.Google Scholar
  36. 36.
    Bonde-Petersen F, Knuttgen HG, Henriksson J. Muscle metabolism during exercise with concentric and eccentric contractions. J Appl Physiol. 1972;33(6):792–5.PubMedGoogle Scholar
  37. 37.
    Armstrong RB, Laughlin MH, Rome L, et al. Metabolism of rats running up and down an incline. J Appl Physiol. 1983;55(2):518–21.PubMedGoogle Scholar
  38. 38.
    Piazzesi G, Francini F, Linari M, et al. Tension transients during steady lengthening of tetanized muscle fibers of the frog. J Physiol. 1992;445:659–711.PubMedGoogle Scholar
  39. 39.
    Huxley AF. Biological motors: energy storage in myosin molecules. Curr Biol. 1998;8(14):R485–8.PubMedCrossRefGoogle Scholar
  40. 40.
    Ryschon TW, Fowler MD, Wysong RE, et al. Efficiency of human skeletal muscle in vivo: comparison of isometric, concentric, and eccentricECC muscle action. J Appl Physiol. 1997;83(3):867–74.PubMedGoogle Scholar
  41. 41.
    Kitamura K, Tokunaga M, Iwane AH, et al. A single myosin head moves along an actin filament with regular steps of 5.3 nanometres. Nature. 1999;397(6715):129–34.PubMedCrossRefGoogle Scholar
  42. 42.
    Lichtneckert SJ, Thomson DA, Colliander Y. Influence of muscle tension variations and energy absorption on oxygen consumption, heart rate, and cardiac output during negative work. Scand J Clin Lab Invest. 1971;27(3):201–5.PubMedCrossRefGoogle Scholar
  43. 43.
    Pasquet B, Carpentier A, Duchateau J. Specific modulation of motor unit discharge for a similar change in fascicle length during shortening and lengthening contractions in humans. J Physiol. 2006;577(Pt 2):753–65.PubMedCrossRefGoogle Scholar
  44. 44.
    Del Valle A, Thomas CK. Firing rates of motor units during strong dynamic contractions. Muscle Nerve. 2005;32(3):316–25.PubMedCrossRefGoogle Scholar
  45. 45.
    Semmler JG, Kornatz KW, Dinenno DV, et al. Motor unit synchronisation is enhanced during slow lengthening contractions of a hand muscle. J Physiol. 2002;545(Pt 2):681–95.PubMedCrossRefGoogle Scholar
  46. 46.
    Grabiner MD, Owings TM. EMG differences between concentric and eccentric maximum voluntary contractions are evident prior to movement onset. Exp Brain Res. 2002;145(4):505–11.PubMedCrossRefGoogle Scholar
  47. 47.
    Fang Y, Siemionow V, Sahgal V, et al. Greater movement-related cortical potential during human eccentric versus concentric muscle contractions. J Neurophysiol. 2001;86(4):1764–72.PubMedGoogle Scholar
  48. 48.
    Gruber M, Linnamo V, Strojnik V, et al. Excitability at the motoneuron pool and motor cortex is specifically modulated in lengthening compared to isometric contractions. J Neurophysiol. 2009;101(4):2030–40.PubMedCrossRefGoogle Scholar
  49. 49.
    Sekiguchi H, Nakazawa K, Suzuki S. Differences in recruitment properties of the corticospinal pathway between lengthening and shortening contractions in human soleus muscle. Brain Res. 2003;977(2):169–79.PubMedCrossRefGoogle Scholar
  50. 50.
    Nordlund MM, Thorstensson A, Cresswell AG. Variations in the soleus H-reflex as a function of activation during controlled lengthening and shortening actions. Brain Res. 2002;952(2):301–7.PubMedCrossRefGoogle Scholar
  51. 51.
    Sekiguchi H, Kimura T, Yamanaka K, et al. Lower excitability of the corticospinal tract to transcranial magnetic stimulation during lengthening contractions in human elbow flexors. Neurosci Lett. 2001;312(2):83–6.PubMedCrossRefGoogle Scholar
  52. 52.
    Knuttgen HG, Klausen K. Oxygen debt in short-term exercise with concentric and eccentric muscle contractions. J Appl Physiol. 1971;30(5):632–5.PubMedGoogle Scholar
  53. 53.
    Pivarnik JM, Sherman NW. Responses of aerobically fit men and women to uphill/downhill walking and slow jogging. Med Sci Sports Exerc. 1990;22(1):127–30.PubMedGoogle Scholar
  54. 54.
    Wanta DM, Nagle FJ, Webb P. Metabolic response to graded downhill walking. Med Sci Sports Exerc. 1993;25(1):159–62.PubMedCrossRefGoogle Scholar
  55. 55.
    Robergs RA, Wagner DR, Skemp KM. Oxygen consumption and energy expenditure of level versus downhill running. J Sports Med Phys Fitness. 1997;37(3):168–74.PubMedGoogle Scholar
  56. 56.
    Overend TJ, Versteegh TH, Thompson E, et al. Cardiovascular stress associated with concentric and eccentric isokinetic exercise in young and older adults. J Gerontol A Biol Sci Med Sci. 2000;55(4):B177–82.PubMedCrossRefGoogle Scholar
  57. 57.
    Paschalis V, Nikolaidis MG, Giakas G, et al. Beneficial changes in energy expenditure and lipid profile after eccentricECC exercise in overweight and lean women. Scand J Med Sci Sports. 2010;20(1):e103–11.PubMedCrossRefGoogle Scholar
  58. 58.
    Hackney KJ, Engels HJ, Gretebeck RJ. Resting energy expenditure and delayed-onset muscle soreness after full-body resistance training with an eccentricECC concentration. J Strength Cond Res. 2008;22(5):1602–9.PubMedCrossRefGoogle Scholar
  59. 59.
    Dolezal BA, Potteiger JA, Jacobsen DJ, et al. Muscle damage and resting metabolic rate after acute resistance exercise with an eccentricECC overload. Med Sci Sports Exerc. 2000;32(7):1202–7.PubMedCrossRefGoogle Scholar
  60. 60.
    Friden J, Lieber RL. Eccentric exercise-induced injuries to contractile and cytoskeletal muscle fiber components. Acta Physiol Scand. 2001;171(3):321–6.PubMedCrossRefGoogle Scholar
  61. 61.
    Howatson G, van Someren KA. The prevention and treatment of exercise-induced muscle damage. Sports Med. 2008;38(6):483–503.PubMedCrossRefGoogle Scholar
  62. 62.
    McHugh MP, Tetro DT. Changes in the relationship between joint angle and torque production associated with the repeated bout effect. J Sports Sci. 2003;21(11):927–32.PubMedCrossRefGoogle Scholar
  63. 63.
    Coffey VG, Zhong Z, Shield A, et al. Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans. FASEB J. 2006;20(1):190–2.PubMedGoogle Scholar
  64. 64.
    Krentz JR, Farthing JP. Neural and morphological changes in response to a 20-day intense eccentric ECC training protocol. Eur J Appl Physiol. 2010;110(2):333–40.PubMedCrossRefGoogle Scholar
  65. 65.
    Chapman D, Newton M, Sacco P, et al. Greater muscle damage induced by fast versus slow velocity eccentric exercise. Int J Sports Med. 2006;27(8):591–8.PubMedCrossRefGoogle Scholar
  66. 66.
    Paschalis V, Koutedakis Y, Baltzopoulos V, et al. Short vs. long length of rectus femoris during eccentric exercise in relation to muscle damage in healthy males. Clin Biomech (Bristol, Avon). 2005;20(6):617–22.Google Scholar
  67. 67.
    Byrne C, Twist C, Eston R. Neuromuscular function after exercise-induced muscle damage: theoretical and applied implications. Sports Med. 2004;34(1):49–69.PubMedCrossRefGoogle Scholar
  68. 68.
    Tee JC, Bosch AN, Lambert MI. Metabolic consequences of exercise-induced muscle damage. Sports Med. 2007;37(10):827–36.PubMedCrossRefGoogle Scholar
  69. 69.
    Jamurtas AZ, Theocharis V, Tofas T, et al. Comparison between leg and arm eccentricECC exercises of the same relative intensity on indices of muscle damage. Eur J Appl Physiol. 2005;95(2–3):179–85.PubMedCrossRefGoogle Scholar
  70. 70.
    Hody S, Leprince P, Sergeant K, et al. Human muscle proteome modifications after acute or repeated eccentric exercises. Med Sci Sports Exerc. 2011;43(12):2281–96.PubMedCrossRefGoogle Scholar
  71. 71.
    Murayama M, Nosaka K, Yoneda T, et al. Changes in hardness of the human elbow flexor muscles after eccentric exercise. Eur J Appl Physiol. 2000;82(5–6):361–7.PubMedCrossRefGoogle Scholar
  72. 72.
    Prasartwuth O, Allen TJ, Butler JE, et al. Length-dependent changes in voluntary activation, maximum voluntary torque and twitch responses after eccentricECC damage in humans. J Physiol. 2006;571(Pt 1):243–52.PubMedGoogle Scholar
  73. 73.
    Leger AB, Milner TE. Muscle function at the wrist after eccentricECC exercise. Med Sci Sports Exerc. 2001;33(4):612–20.PubMedGoogle Scholar
  74. 74.
    Dartnall TJ, Rogasch NC, Nordstrom MA, et al. Eccentric muscle damage has variable effects on motor unit recruitment thresholds and discharge patterns in elbow flexor muscles. J Neurophysiol. 2009;102(1):413–23.PubMedCrossRefGoogle Scholar
  75. 75.
    Dartnall TJ, Nordstrom MA, Semmler JG. Adaptations in biceps brachii motor unit activity after repeated bouts of eccentric exercise in elbow flexor muscles. J Neurophysiol. 2011;105(3):1225–35.PubMedCrossRefGoogle Scholar
  76. 76.
    Eston RG, Mickleborough J, Baltzopoulos V. Eccentric activation and muscle damage: biomechanical and physiological considerations during downhill running. Br J Sports Med. 1995;29(2):89–94.PubMedCrossRefGoogle Scholar
  77. 77.
    Eston RG, Lemmey AB, McHugh P, et al. Effect of stride length on symptoms of exercise-induced muscle damage during a repeated bout of downhill running. Scand J Med Sci Sports. 2000;10(4):199–204.PubMedCrossRefGoogle Scholar
  78. 78.
    Totsuka M, Nakaji S, Suzuki K, et al. Break point of serum creatine kinase release after endurance exercise. J Appl Physiol. 2002;93(4):1280–6.PubMedGoogle Scholar
  79. 79.
    Sayers SP, Clarkson PM. Short-term immobilization after eccentric exercise. Part II: creatine kinase and myoglobin. Med Sci Sports Exerc. 2003;35(5):762–8.PubMedCrossRefGoogle Scholar
  80. 80.
    Lin H, Chie W, Lien H. Epidemiological analysis of factors influencing an episode of exertional rhabdomyolysis in high school students. Am J Sports Med. 2006;34(3):481–6.PubMedCrossRefGoogle Scholar
  81. 81.
    Alpers JP, Jones LK Jr. Natural history of exertional rhabdomyolysis: a population-based analysis. Muscle Nerve. 2010;42(4):487–91.PubMedCrossRefGoogle Scholar
  82. 82.
    Asmussen E. Positive and negative muscular work. Acta Physiol Scand. 1953;28(4):364–82.PubMedCrossRefGoogle Scholar
  83. 83.
    Morgan DL, Proske U. Popping sarcomere hypothesis explains stretch-induced muscle damage. Clin Exp Pharmacol Physiol. 2004;31(8):541–5.PubMedCrossRefGoogle Scholar
  84. 84.
    Morgan DL, Proske U. Sarcomere popping requires stretch over a range where total tension decreases with length. J Physiol. 2006, 15;574(Pt 2):627–8; author reply 9–30.Google Scholar
  85. 85.
    Telley IA, Stehle R, Ranatunga KW, et al. Dynamic behaviour of half-sarcomeres during and after stretch in activated rabbit psoas myofibrils: sarcomere asymmetry but no ‘sarcomere popping’. J Physiol. 2006;573(Pt 1):173–85.Google Scholar
  86. 86.
    Allen DG, Whitehead NP, Yeung EW. Mechanisms of stretch-induced muscle damage in normal and dystrophic muscle: role of ionic changes. J Physiol. 2005;567(Pt 3):723–35.PubMedCrossRefGoogle Scholar
  87. 87.
    Butterfield TA. Eccentric exercise in vivo: strain-induced muscle damage and adaptation in a stable system. Exerc Sport Sci Rev. 2010;38(2):51–60.PubMedCrossRefGoogle Scholar
  88. 88.
    Schoenfeld BJ. Does exercise-induced muscle damage play a role in skeletal muscle hypertrophy? J Strength Cond Res. 2012;26(5):1441–53.Google Scholar
  89. 89.
    Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol. 2000;279(6):L1005–28.PubMedGoogle Scholar
  90. 90.
    Ji LL, Gomez-Cabrera MC, Vina J. Exercise and hormesis: activation of cellular antioxidant signaling pathway. Ann N Y Acad Sci. 2006;1067:425–35.PubMedCrossRefGoogle Scholar
  91. 91.
    Gomez-Cabrera MC, Domenech E, Vina J. Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radic Biol Med. 2008;44(2):126–31.PubMedCrossRefGoogle Scholar
  92. 92.
    Jackson MJ. Free radicals generated by contracting muscle: by-products of metabolism or key regulators of muscle function? Free Radic Biol Med. 2008;44(2):132–41.PubMedCrossRefGoogle Scholar
  93. 93.
    Friden J, Seger J, Sjostrom M, et al. Adaptive response in human skeletal muscle subjected to prolonged eccentricECC training. Int J Sports Med. 1983;4(3):177–83.PubMedCrossRefGoogle Scholar
  94. 94.
    Gibala MJ, MacDougall JD, Tarnopolsky MA, et al. Changes in human skeletal muscle ultrastructure and force production after acute resistance exercise. J Appl Physiol. 1995;78(2):702–8.PubMedGoogle Scholar
  95. 95.
    Proske U, Morgan DL. Muscle damage from eccentricECC exercise: mechanism, mechanical signs, adaptation and clinical applications. J Physiol. 2001;537(Pt 2):333–45.PubMedCrossRefGoogle Scholar
  96. 96.
    Lieber RL, Friden J. Mechanisms of muscle injury gleaned from animal models. Am J Phys Med Rehabil. 2002;81(11 Suppl):S70–9.PubMedCrossRefGoogle Scholar
  97. 97.
    Lauritzen F, Paulsen G, Raastad T, et al. Gross ultrastructural changes and necrotic fiber segments in elbow flexor muscles after maximal voluntary eccentricECC action in humans. J Appl Physiol. 2009;107(6):1923–34.PubMedCrossRefGoogle Scholar
  98. 98.
    Paulsen G, Crameri R, Benestad HB, et al. Time course of leukocyte accumulation in human muscle after eccentric exercise. Med Sci Sports Exerc. 2010;42(1):75–85.PubMedCrossRefGoogle Scholar
  99. 99.
    Nurenberg P, Giddings CJ, Stray-Gundersen J, et al. MR imaging-guided muscle biopsy for correlation of increased signal intensity with ultrastructural change and delayed-onset muscle soreness after exercise. Radiology. 1992;184(3):865–9.PubMedGoogle Scholar
  100. 100.
    Yu JG, Carlsson L, Thornell LE. Evidence for myofibril remodeling as opposed to myofibril damage in human muscles with DOMS: an ultrastructural and immunoelectron microscopic study. Histochem Cell Biol. 2004;121(3):219–27.PubMedCrossRefGoogle Scholar
  101. 101.
    Crameri RM, Aagaard P, Qvortrup K, et al. Myofiber damage in human skeletal muscle: effects of electrical stimulation versus voluntary contraction. J Physiol. 2007;583(Pt 1):365–80.PubMedCrossRefGoogle Scholar
  102. 102.
    Friden J, Lieber RL. Segmental muscle fiber lesions after repetitive eccentric contractions. Cell Tissue Res. 1998;293(1):165–71.PubMedCrossRefGoogle Scholar
  103. 103.
    Sorichter S, Mair J, Koller A, et al. Creatine kinase, myosin heavy chains and magnetic resonance imaging after eccentric exercise. J Sports Sci. 2001;19(9):687–91.PubMedCrossRefGoogle Scholar
  104. 104.
    Yanagisawa O, Kurihara T, Kobayashi N, et al. Strenuous resistance exercise effects on magnetic resonance diffusion parameters and muscle-tendon function in human skeletal muscle. J Magn Reson Imaging. 2011;34(4):887–94.PubMedCrossRefGoogle Scholar
  105. 105.
    Cermak NM, Noseworthy MD, Bourgeois JM, T et al. Diffusion tensor MRI to assess skeletal muscle disruption following eccentricECC exercise. Muscle Nerve. 2012;46(1):42–50.Google Scholar
  106. 106.
    Brancaccio P, Lippi G, Maffulli N. Biochemical markers of muscular damage. Clin Chem Lab Med. 2010;48(6):757–67.PubMedCrossRefGoogle Scholar
  107. 107.
    Chapman DW, Simpson JA, Iscoe S, et al. Changes in serum fast and slow skeletal troponin I concentration following maximal eccentric contractions. J Sci Med Sport. 2013;16(1):82–5.Google Scholar
  108. 108.
    Baird MF, Graham SM, Baker JS, et al. Creatine-kinase- and exercise-related muscle damage implications for muscle performance and recovery. J Nutr Metab. 2012; article ID960363: doi: 10.1155/2012/960363.
  109. 109.
    Munehiro T, Kitaoka K, Ueda Y, et al. Establishment of an animal model for delayed-onset muscle soreness after high-intensity eccentric exercise and its application for investigating the efficacy of low-load eccentric training. J Orthop Sci. 2012;17(3):244–52.PubMedCrossRefGoogle Scholar
  110. 110.
    Gibala MJ, Interisano SA, Tarnopolsky MA, et al. Myofibrillar disruption following acute concentric and eccentric resistance exercise in strength-trained men. Can J Physiol Pharmacol. 2000;78(8):656–61.PubMedCrossRefGoogle Scholar
  111. 111.
    Meier WA, Marcus RL, Dibble LE, et al. The long-term contribution of muscle activation and muscle size to quadriceps weakness following total knee arthroplasty. J Geriatr Phys Ther. 2009;32(2):79–82.PubMedCrossRefGoogle Scholar
  112. 112.
    McHugh MP. Recent advances in the understanding of the repeated bout effect: the protective effect against muscle damage from a single bout of eccentric exercise. Scand J Med Sci Sports. 2003;13(2):88–97.PubMedCrossRefGoogle Scholar
  113. 113.
    Howatson G, Van Someren K, Hortobagyi T. Repeated bout effect after maximal eccentric exercise. Int J Sports Med. 2007;28(7):557–63.PubMedCrossRefGoogle Scholar
  114. 114.
    Nosaka K, Clarkson PM. Muscle damage following repeated bouts of high force eccentric exercise. Med Sci Sports Exerc. 1995;27(9):1263–9.PubMedGoogle Scholar
  115. 115.
    Howatson G, van Someren KA. Evidence of a contralateral repeated bout effect after maximal eccentric contractions. Eur J Appl Physiol. 2007;101(2):207–14.PubMedCrossRefGoogle Scholar
  116. 116.
    Starbuck C, Eston RG. Exercise-induced muscle damage and the repeated bout effect: evidence for cross transfer. Eur J Appl Physiol. 2012;112(3):1005–13.PubMedCrossRefGoogle Scholar
  117. 117.
    Barash IA, Peters D, Friden J, et al. Desmin cytoskeletal modifications after a bout of eccentric exercise in the rat. Am J Physiol Regul Integr Comp Physiol. 2002;283(4):R958–63.PubMedGoogle Scholar
  118. 118.
    Lapier TK, Burton HW, Almon R, et al. Alterations in intramuscular connective tissue after limb casting affect contraction-induced muscle injury. J Appl Physiol. 1995;78(3):1065–9.PubMedGoogle Scholar
  119. 119.
    Morgan DL. New insights into the behavior of muscle during active lengthening. Biophys J. 1990;57(2):209–21.PubMedCrossRefGoogle Scholar
  120. 120.
    Lynn R, Morgan DL. Decline running produces more sarcomeres in rat vastus intermedius muscle fibers than does incline running. J Appl Physiol. 1994;77(3):1439–44.PubMedGoogle Scholar
  121. 121.
    Lynn R, Talbot JA, Morgan DL. Differences in rat skeletal muscles after incline and decline running. J Appl Physiol. 1998;85(1):98–104.PubMedGoogle Scholar
  122. 122.
    Brockett CL, Morgan DL, Proske U. Human hamstring muscles adapt to eccentric exercise by changing optimum length. Med Sci Sports Exerc. 2001;33(5):783–90.PubMedGoogle Scholar
  123. 123.
    Lastayo PC, Reich TE, Urquhart M, et al. Chronic eccentric exercise: improvements in muscle strength can occur with little demand for oxygen. Am J Physiol. 1999;276(2 Pt 2):R611–5.PubMedGoogle Scholar
  124. 124.
    LaStayo PC, Pierotti DJ, Pifer J, et al. Eccentric ergometry: increases in locomotor muscle size and strength at low training intensities. Am J Physiol Regul Integr Comp Physiol. 2000;278(5):R1282–8.PubMedGoogle Scholar
  125. 125.
    LaStayo PC, Ewy GA, Pierotti DD, et al. The positive effects of negative work: increased muscle strength and decreased fall risk in a frail elderly population. J Gerontol A Biol Sci Med Sci. 2003;58(5):M419–24.PubMedCrossRefGoogle Scholar
  126. 126.
    LaStayo PC, Meier W, Marcus RL, et al. Reversing muscle and mobility deficits 1 to 4 years after TKA: a pilot study. Clin Orthop Relat Res. 2009;467(6):1493–500.PubMedCrossRefGoogle Scholar
  127. 127.
    Hortobagyi T, Hill JP, Houmard JA, et al. Adaptive responses to muscle lengthening and shortening in humans. J Appl Physiol. 1996;80(3):765–72.PubMedGoogle Scholar
  128. 128.
    Chen TC, Chen HL, Pearce AJ, et al. Attenuation of eccentric exercise-induced muscle damage by preconditioning exercises. Med Sci Sports Exerc. 2012;44(11):2090–8.Google Scholar
  129. 129.
    Ingham SA, van Someren KA, Howatson G. Effect of a concentric warm-up exercise on eccentrically induced soreness and loss of function of the elbow flexor muscles. J Sports Sci. 2010;28(13):1377–82.PubMedCrossRefGoogle Scholar
  130. 130.
    Meyer K, Steiner R, Lastayo P, et al. Eccentric exercise in coronary patients: central hemodynamic and metabolic responses. Med Sci Sports Exerc. 2003;35(7):1076–82.PubMedCrossRefGoogle Scholar
  131. 131.
    Rocha Vieira DS, Baril J, Richard R, et al. Eccentric cycle exercise in severe COPD: feasibility of application. COPD. 2011;8(4):270–4.Google Scholar
  132. 132.
    Reeves ND, Maganaris CN, Longo S, et al. Differential adaptations to eccentric versus conventional resistance training in older humans. Exp Physiol. 2009;94(7):825–33.Google Scholar
  133. 133.
    Gross M, Luthy F, Kroell J, et al. Effects of eccentric cycle ergometry in alpine skiers. Int J Sports Med. 2010;31(8):572–6.PubMedCrossRefGoogle Scholar
  134. 134.
    Steiner R, Meyer K, Lippuner K, et al. Eccentric endurance training in subjects with coronary artery disease: a novel exercise paradigm in cardiac rehabilitation? Eur J Appl Physiol. 2004;91(5–6):572–8.Google Scholar
  135. 135.
    Dibble LE, Hale TF, Marcus RL, et al. High-intensity resistance training amplifies muscle hypertrophy and functional gains in persons with Parkinson’s disease. Mov Disord. 2006;21(9):1444–52.PubMedCrossRefGoogle Scholar
  136. 136.
    Dibble LE, Hale TF, Marcus RL, et al. High intensity eccentric resistance training decreases bradykinesia and improves quality of life in persons with Parkinson’s disease: a preliminary study. Parkinsonism Relat Disord. 2009;15(10):752–7.PubMedCrossRefGoogle Scholar
  137. 137.
    LaStayo PC, Marcus RL, Dibble LE, et al. Eccentric exercise versus usual-care with older cancer survivors: the impact on muscle and mobility. An exploratory pilot study. BMC Geriatr. 2011;11:5.PubMedCrossRefGoogle Scholar
  138. 138.
    Miller LE, Pierson LM, Nickols-Richardson SM, et al. Knee extensor and flexor torque development with concentric and eccentric isokinetic training. Res Q Exerc Sport. 2006;77(1):58–63.PubMedGoogle Scholar
  139. 139.
    Blazevich AJ, Cannavan D, Coleman DR, et al. Influence of concentric and eccentric resistance training on architectural adaptation in human quadriceps muscles. J Appl Physiol. 2007;103(5):1565–75.PubMedCrossRefGoogle Scholar
  140. 140.
    Vikne H, Refsnes PE, Ekmark M, et al. Muscular performance after concentric and eccentric exercise in trained men. Med Sci Sports Exerc. 2006;38(10):1770–81.PubMedCrossRefGoogle Scholar
  141. 141.
    Nickols-Richardson SM, Miller LE, Wootten DF, et al. Concentric and eccentric isokinetic resistance training similarly increases muscular strength, fat-free soft tissue mass, and specific bone mineral measurements in young women. Osteoporos Int. 2007;18(6):789–96.PubMedCrossRefGoogle Scholar
  142. 142.
    Komi PV, Buskirk ER. Effect of eccentric and concentric muscle conditioning on tension and electrical activity of human muscle. Ergonomics. 1972;15(4):417–34.PubMedCrossRefGoogle Scholar
  143. 143.
    Paddon-Jones D, Leveritt M, Lonergan A, et al. Adaptation to chronic eccentric exercise in humans: the influence of contraction velocity. Eur J Appl Physiol. 2001;85(5):466–71.PubMedCrossRefGoogle Scholar
  144. 144.
    Farthing JP, Chilibeck PD. The effect of eccentric training at different velocities on cross-education. Eur J Appl Physiol. 2003;89(6):570–7.PubMedCrossRefGoogle Scholar
  145. 145.
    Shepstone TN, Tang JE, Dallaire S, et al. Short-term high- vs. low-velocity isokinetic lengthening training results in greater hypertrophy of the elbow flexors in young men. J Appl Physiol. 2005;98(5):1768–76.PubMedCrossRefGoogle Scholar
  146. 146.
    Friedmann-Bette B, Bauer T, Kinscherf R, et al. Effects of strength training with eccentric overload on muscle adaptation in male athletes. Eur J Appl Physiol. 2010;108(4):821–36.PubMedCrossRefGoogle Scholar
  147. 147.
    Guilhem G, Cornu C, Guevel A. Neuromuscular and muscle-tendon system adaptations to isotonic and isokinetic eccentric exercise. Ann Phys Rehabil Med. 2010;53(5):319–41.PubMedCrossRefGoogle Scholar
  148. 148.
    Hortobagyi T, Dempsey L, Fraser D, et al. Changes in muscle strength, muscle fiber size and myofibrillar gene expression after immobilization and retraining in humans. J Physiol. 2000;524(Pt 1):293–304.PubMedCrossRefGoogle Scholar
  149. 149.
    Higbie EJ, Cureton KJ, Warren GL 3rd, et al. Effects of concentric and eccentric training on muscle strength, cross-sectional area, and neural activation. J Appl Physiol. 1996;81(5):2173–81.PubMedGoogle Scholar
  150. 150.
    Lynch GS, Fary CJ, Williams DA. Quantitative measurement of resting skeletal muscle [Ca2+]i following acute and long-term downhill running exercise in mice. Cell Calcium. 1997;22(5):373–83.PubMedCrossRefGoogle Scholar
  151. 151.
    Mahieu NN, McNair P, Cools A, et al. Effect of eccentric training on the plantar flexor muscle-tendon tissue properties. Med Sci Sports Exerc. 2008;40(1):117–23.PubMedGoogle Scholar
  152. 152.
    Cermak NM, Snijders T, McKay BR, et al. Eccentric exercise increases satellite cell content in type II muscle fibers. Med Sci Sports Exerc. 2013; 45:230–7.Google Scholar
  153. 153.
    Zoll J, Steiner R, Meyer K, et al. Gene expression in skeletal muscle of coronary artery disease patients after concentric and eccentric endurance training. Eur J Appl Physiol. 2006;96(4):413–22.PubMedCrossRefGoogle Scholar
  154. 154.
    Hortobagyi T, Barrier J, Beard D, et al. Greater initial adaptations to submaximal muscle lengthening than maximal shortening. J Appl Physiol. 1996;81(4):1677–82.PubMedGoogle Scholar
  155. 155.
    Duclay J, Martin A, Robbe A, et al. Spinal reflex plasticity during maximal dynamic contractions after eccentric training. Med Sci Sports Exerc. 2008;40(4):722–34.PubMedCrossRefGoogle Scholar
  156. 156.
    Pensini M, Martin A, Maffiuletti NA. Central versus peripheral adaptations following eccentric resistance training. Int J Sports Med. 2002;23(8):567–74.PubMedCrossRefGoogle Scholar
  157. 157.
    Carroll TJ, Selvanayagam VS, Riek S, et al. Neural adaptations to strength training: moving beyond transcranial magnetic stimulation and reflex studies. Acta Physiol (Oxf). 2011;202(2):119–40.CrossRefGoogle Scholar
  158. 158.
    Malliaropoulos N, Mendiguchia J, Pehlivanidis H, et al. Hamstring exercises for track and field athletes: injury and exercise biomechanics, and possible implications for exercise selection and primary prevention. Br J Sports Med. 2012;46(12):846–51.PubMedCrossRefGoogle Scholar
  159. 159.
    Mjolsnes R, Arnason A, Osthagen T, et al. A 10-week randomized trial comparing eccentric vs. concentric hamstring strength training in well-trained soccer players. Scand J Med Sci Sports. 2004;14(5):311–7.PubMedCrossRefGoogle Scholar
  160. 160.
    Greenstein JS, Bishop BN, Edward JS, et al. The effects of a closed-chain, eccentric training program on hamstring injuries of a professional football cheerleading team. J Mani Physiol Ther. 2011;34(3):195–200.Google Scholar
  161. 161.
    Petersen J, Thorborg K, Nielsen MB, et al. Preventive effect of eccentric training on acute hamstring injuries in men’s soccer: a cluster-randomized controlled trial. Am J Sports Med. 2011;39(11):2296–303.PubMedCrossRefGoogle Scholar
  162. 162.
    Iga J, Fruer CS, Deighan M, et al. ‘Nordic’ hamstrings exercise: engagement characteristics and training responses. Int J Sports Med. 2012; 33:1000–4.Google Scholar
  163. 163.
    Cook CJ, Beaven CM, Kilduff LP. Three weeks of eccentric training combined with over-speed exercises enhances power and running speed performance gains in trained athletes. J Strength Cond Res. Epub 2012 Jul 18.Google Scholar
  164. 164.
    Ellenbecker TS, Davies GJ, Rowinski MJ. Concentric versus eccentric isokinetic strengthening of the rotator cuff. Objective data versus functional test. Am J Sports Med. 1988;16(1):64–9.Google Scholar
  165. 165.
    Mont MA, Cohen DB, Campbell KR, et al. Isokinetic concentric versus eccentric training of shoulder rotators with functional evaluation of performance enhancement in elite tennis players. Am J Sports Med. 1994;22(4):513–7.Google Scholar
  166. 166.
    Young MA, Cook JL, Purdam CR, et al. Eccentric decline squat protocol offers superior results at 12 months compared with traditional eccentric protocol for patellar tendinopathy in volleyball players. Br J Sports Med. 2005;39(2):102–5.PubMedCrossRefGoogle Scholar
  167. 167.
    Langberg H, Ellingsgaard H, Madsen T, et al. Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis. Scand J Med Sci Sports. 2007;17(1):61–6.PubMedGoogle Scholar
  168. 168.
    Collado H, Coudreuse JM, Graziani F, et al. Eccentric reinforcement of the ankle evertor muscles after lateral ankle sprain. Scand J Med Sci Sports. 2010;20(2):241–6.PubMedCrossRefGoogle Scholar
  169. 169.
    Hortobagyi T, Lambert NJ, Hill JP. Greater cross education following training with muscle lengthening than shortening. Med Sci Sports Exerc. 1997;29(1):107–12.PubMedCrossRefGoogle Scholar
  170. 170.
    Scripture EW, Smith TL, Brown EM. On the education of muscular control and power. Stud Yale Psychol Lab. 1894;2:114–9.Google Scholar
  171. 171.
    Lee M, Carroll TJ. Cross education: possible mechanisms for the contralateral effects of unilateral resistance training. Sports Med. 2007;37(1):1–14.PubMedCrossRefGoogle Scholar
  172. 172.
    Carroll TJ, Herbert RD, Munn J, et al. Contralateral effects of unilateral strength training: evidence and possible mechanisms. J Appl Physiol. 2006;101(5):1514–22.PubMedCrossRefGoogle Scholar
  173. 173.
    Lindstedt SL, Reich TE, Keim P, et al. Do muscles function as adaptable locomotor springs? J Exp Biol. 2002;205(Pt 15):2211–6.Google Scholar
  174. 174.
    Elmer S, Hahn S, McAllister P, et al. Improvements in multi-joint leg function following chronic eccentric exercise. Scand J Med Sci Sports. 2012;22(5):653–61.Google Scholar
  175. 175.
    Gerber JP, Marcus RL, Dibble LE, et al. Effects of early progressive eccentric exercise on muscle structure after anterior cruciate ligament reconstruction. J Bone Joint Surg Am. 2007;89(3):559–70.PubMedCrossRefGoogle Scholar
  176. 176.
    Gerber JP, Marcus RL, Dibble LE, et al. Safety, feasibility, and efficacy of negative work exercise via eccentric muscle activity following anterior cruciate ligament reconstruction. J Orthop Sports Phys Ther. 2007;37(1):10–8.PubMedCrossRefGoogle Scholar
  177. 177.
    Gerber JP, Marcus RL, Dibble LE, et al. Effects of early progressive eccentric exercise on muscle size and function after anterior cruciate ligament reconstruction: a 1-year follow-up study of a randomized clinical trial. Phys Ther. 2009;89(1):51–9.PubMedCrossRefGoogle Scholar
  178. 178.
    Masud T, Morris RO. Epidemiology of falls. Age Ageing. 2001;30(Suppl. 4):3–7.PubMedCrossRefGoogle Scholar
  179. 179.
    Corso P, Finkelstein E, Miller T, et al. Incidence and lifetime costs of injuries in the United States. Inj Prev. 2006;12(4):212–8.PubMedCrossRefGoogle Scholar
  180. 180.
    Hartholt KA, van Beeck EF, Polinder S, et al. Societal consequences of falls in the older population: injuries, healthcare costs, and long-term reduced quality of life. J Trauma. 2010;71(3):748–53.CrossRefGoogle Scholar
  181. 181.
    Heinrich S, Deister A, Birker T, et al. Accuracy of self-reports of mental health care utilization and calculated costs compared to hospital records. Psychiatry Res. 2012;185(1–2):261–8.Google Scholar
  182. 182.
    Hortobagyi T, DeVita P. Favorable neuromuscular and cardiovascular responses to 7 days of exercise with an eccentric overload in elderly women. J Gerontol A Biol Sci Med Sci. 2000;55(8):B401–10.PubMedCrossRefGoogle Scholar
  183. 183.
    Valour D, Rouji M, Pousson M. Effects of eccentric training on torque-angular velocity-power characteristics of elbow flexor muscles in older women. Exp Gerontol. 2004;39(3):359–68.PubMedCrossRefGoogle Scholar
  184. 184.
    Symons TB, Vandervoort AA, Rice CL, et al. Effects of maximal isometric and isokinetic resistance training on strength and functional mobility in older adults. J Gerontol A Biol Sci Med Sci. 2005;60(6):777–81.PubMedCrossRefGoogle Scholar
  185. 185.
    Leszczak TJ, Olson JM, Stafford J, et al. Early adaptations to eccentric and high velocity training on strength and functional performance in community dwelling older adults. J Strength Cond Res. 2013;27(2):442–8.Google Scholar
  186. 186.
    Raj IS, Bird SR, Westfold BA, et al. Effects of eccentrically biased versus conventional weight training in older adults. Med Sci Sports Exerc. 2012;44(6):1167–76.PubMedCrossRefGoogle Scholar
  187. 187.
    Mueller M, Breil FA, Vogt M, et al. Different response to eccentric and concentric training in older men and women. Eur J Appl Physiol. 2009;107(2):145–53.PubMedCrossRefGoogle Scholar
  188. 188.
    Gault ML, Clements RE, Willems ME. Functional mobility of older adults after concentric and eccentric endurance exercise. Eur J Appl Physiol. 2012;112:3699–707.Google Scholar
  189. 189.
    Mueller M, Breil FA, Lurman G, et al. Different molecular and structural adaptations with eccentric and conventional strength training in elderly men and women. Gerontology. 2011;57(6):528–38.PubMedCrossRefGoogle Scholar
  190. 190.
    Gremeaux V, Duclay J, Deley G, et al. Does eccentric endurance training improve walking capacity in patients with coronary artery disease? A randomized controlled pilot study. Clin Rehabil. 2010;24(7):590–9.PubMedCrossRefGoogle Scholar
  191. 191.
    Rooyackers JM, Berkeljon DA, Folgering HT. Eccentric exercise training in patients with chronic obstructive pulmonary disease. Int J Rehabil Res. 2003;26(1):47–9.PubMedCrossRefGoogle Scholar
  192. 192.
    Eriksson J, Taimela S, Eriksson K, et al. Resistance training in the treatment of non-insulin-dependent diabetes mellitus. Int J Sports Med. 1997;18(4):242–6.PubMedCrossRefGoogle Scholar
  193. 193.
    Christ-Roberts CY, Pratipanawatr T, Pratipanawatr W, et al. Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects. Metabolism. 2004;53(9):1233–42.PubMedCrossRefGoogle Scholar
  194. 194.
    Paschalis V, Nikolaidis MG, Theodorou AA, et al. A weekly bout of eccentric exercise is sufficient to induce health-promoting effects. Med Sci Sports Exerc. 2011;43(1):64–73.PubMedCrossRefGoogle Scholar
  195. 195.
    Robineau S, Nicolas B, Gallien P, et al. EccentricECC isokinetic strengthening in hamstrings of patients with multiple sclerosis [in French]. Ann Readapt Med Phys. 2005;48(1):29–33.PubMedCrossRefGoogle Scholar
  196. 196.
    Hayes HA, Gappmaier E, LaStayo PC. Effects of high-intensity resistance training on strength, mobility, balance, and fatigue in individuals with multiple sclerosis: a randomized controlled trial. J Neurol Phys Ther. 2011;35(1):2–10.PubMedGoogle Scholar
  197. 197.
    Sweeney C, Schmitz KH, Lazovich D, et al. Functional limitations in elderly female cancer survivors. J Natl Cancer Inst. 2006;98(8):521–9.PubMedCrossRefGoogle Scholar
  198. 198.
    Galvao DA, Taaffe DR, Spry N, et al. Reduced muscle strength and functional performance in men with prostate cancer undergoing androgen suppression: a comprehensive cross-sectional investigation. Prostate Cancer Prostatic Dis. 2009;12(2):198–203.PubMedCrossRefGoogle Scholar
  199. 199.
    De Backer IC, Schep G, Backx FJ. Eccentric isokinetic strengthening in hamstrings of patients with multiple sclerosis. Resistance training in cancer survivors: a systematic review. Int J Sports Med. 2009;30(10):703–12.PubMedCrossRefGoogle Scholar
  200. 200.
    Hansen PA, Dechet CB, Porucznik CA, et al. Comparing eccentric resistance exercise in prostate cancer survivors on and off hormone therapy: a pilot study. PM R. 2009;1(11):1019–24.PubMedCrossRefGoogle Scholar
  201. 201.
    Duncan PW, Chandler JM, Cavanaugh DK, et al. Mode and speed specificity of eccentric and concentric exercise training. J Orthop Sports Phys Ther. 1989;11(2):70–5.PubMedGoogle Scholar
  202. 202.
    Colliander EB, Tesch PA. Effects of eccentric and concentric muscle actions in resistance training. Acta Physiol Scand. 1990;140(1):31–9.PubMedCrossRefGoogle Scholar
  203. 203.
    Tesch PA, Thorsson A, Colliander EB. Effects of eccentric and concentric resistance training on skeletal muscle substrates, enzyme activities and capillary supply. Acta Physiol Scand. 1990;140(4):575–80.PubMedCrossRefGoogle Scholar
  204. 204.
    Hather BM, Tesch PA, Buchanan P, et al. Influence of eccentric actions on skeletal muscle adaptations to resistance training. Acta Physiol Scand. 1991;143(2):177–85.PubMedCrossRefGoogle Scholar
  205. 205.
    Tomberlin JP, Basford JR, Schwen EE, et al. Comparative study of isokinetic eccentric and concentric quadriceps training. J Orthop Sports Phys Ther. 1991;14(1):31–6.PubMedGoogle Scholar
  206. 206.
    Smith RC, Rutherford OM. The role of metabolites in strength training. I: a comparison of eccentric and concentric contractions. Eur J Appl Physiol Occup Physiol. 1995;71(4):332–6.PubMedCrossRefGoogle Scholar
  207. 207.
    Ben-Sira D, Ayalon A, Tavi M. The effects of different types of strength training on concentric strength in women. J Strength Cond Res. 1995;9:143–8.Google Scholar
  208. 208.
    Mayhew TP, Rothstein JM, Finucane SD, et al. Muscular adaptation to concentric and eccentric exercise at equal power levels. Med Sci Sports Exerc. 1995;27(6):868–73.PubMedGoogle Scholar
  209. 209.
    Weir JP, Housh DJ, Housh TJ, et al. The effect of unilateral eccentric weight training and detraining on joint angle specificity, cross-training, and the bilateral deficit. J Orthop Sports Phys Ther. 1995;22(5):207–15.PubMedGoogle Scholar
  210. 210.
    Seger JY, Arvidsson B, Thorstensson A. Specific effects of eccentric and concentric training on muscle strength and morphology in humans. Eur J Appl Physiol Occup Physiol. 1998;79(1):49–57.PubMedCrossRefGoogle Scholar
  211. 211.
    Farthing JP, Chilibeck PD. The effects of eccentric and concentric training at different velocities on muscle hypertrophy. Eur J Appl Physiol. 2003;89(6):578–86.PubMedCrossRefGoogle Scholar
  212. 212.
    Raue U, Terpstra B, Williamson DL, et al. Effects of short-term concentric vs. eccentric resistance training on single muscle fiber MHC distribution in humans. Int J Sports Med. 2005;26(5):339–43.PubMedCrossRefGoogle Scholar
  213. 213.
    Seger JY, Thorstensson A. Effects of eccentric versus concentric training on thigh muscle strength and EMG. Int J Sports Med. 2005;26(1):45–52.Google Scholar
  214. 214.
    Gabbe BJ, Branson R, Bennell KL. A pilot randomised controlled trial of eccentric exercise to prevent hamstring injuries in community-level Australian Football. J Sci Med Sport. 2006;9(1–2):103–9.PubMedCrossRefGoogle Scholar
  215. 215.
    Norrbrand L, Fluckey JD, Pozzo M, et al. Resistance training using eccentric overload induces early adaptations in skeletal muscle size. Eur J Appl Physiol. 2008;102(3):271–81.PubMedCrossRefGoogle Scholar
  216. 216.
    Potier TG, Alexander CM, Seynnes OR. Effects of eccentric strength training on biceps femoris muscle architecture and knee joint range of movement. Eur J Appl Physiol. 2009;105(6):939–44.PubMedCrossRefGoogle Scholar
  217. 217.
    LaStayo P, McDonagh P, Lipovic D, et al. Elderly patients and high force resistance exercise: a descriptive report. Can an anabolic, muscle growth response occur without muscle damage or inflammation? J Geriatr Phys Ther. 2007;30(3):128–34.PubMedCrossRefGoogle Scholar
  218. 218.
    Melo RC, Quiterio RJ, Takahashi AC, et al. High eccentric strength training reduces heart rate variability in healthy older men. Br J Sports Med. 2008;42(1):59–63.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  • Marie-Eve Isner-Horobeti
    • 1
    • 2
    • 10
  • Stéphane Pascal Dufour
    • 2
    • 3
  • Philippe Vautravers
    • 1
  • Bernard Geny
    • 2
    • 4
  • Emmanuel Coudeyre
    • 5
  • Ruddy Richard
    • 2
    • 6
    • 7
    • 8
    • 9
  1. 1.Physical and Rehabilitation Medicine Department, Strasbourg University Rehabilitation Institute-ClémenceauStrasbourg UniversityStrasbourgFrance
  2. 2.Strasbourg University, Federation of Translational Medicine, EA 3072 “Mitochondrie, stress oxydant et protection musculaire”StrasbourgFrance
  3. 3.Faculty of Sports SciencesStrasbourg UniversityStrasbourgFrance
  4. 4.Department of Physiology and Functional Explorations, NHCStrasbourg UniversityStrasbourgFrance
  5. 5.Physical and Rehabilitation Medicine Department, Hôpital NordUniversity Hospital Clermont-FerrandClermont-FerrandFrance
  6. 6.Department of Sport Medicine and Functional Explorations, Hôpital G. MontpiedUniversity Hospital Clermont-FerrandClermont-FerrandFrance
  7. 7.INRA, UMR, 1019Clermont-FerrandFrance
  8. 8.UFR MédecineUniversity of Clermont 1Clermont-FerrandFrance
  9. 9.CRNH-AuvergneClermont-FerrandFrance
  10. 10.Institut Universitaire de Réadaptation Clémenceau-StrasbourgStrasbourgFrance

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