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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 30-year-old man developed invasive aspergillosis with cerebral and ocular involvement following treatment with ruxolitinib, tacrolimus, budesonide and prednisone for a cutaneous and digestive graft versus host disease. Additionally, he experienced lack of efficacy following antifungal treatment with posaconazole, voriconazole and amphotericin B for invasive aspergillosis [not all routes and dosages stated; durations of treatments to reactions onsets not stated].
The man had acute myeloblastic leukaemia in complete remission with minimal negative residual disease and secondary myelodysplastic syndrome. He was hospitalised on 6 October 2017 for bilateral pneumonia of mixed aetiology due to Pseudomonas aeruginosa (isolated in blood cultures and sputa) and Aspergillus sp. (isolati...
- Moruno-Rodriguez A, et al. Invasive aspergillosis manifesting as retinal necrosis in a patient treated with ruxolitinib. Archivos de la Sociedad Espanola de Oftalmologia 94: 237-241, No. 5, May 2019. Available from: URL: http://doi.org/10.1016/j.oftal.2018.12.006 [Spanish; summarised from a translation]CrossRefGoogle Scholar