Reactions Weekly

, Volume 1786, Issue 1, pp 29–29 | Cite as


Invasive aspergillosis with cerebral and ocular involvement and lack of efficacy: case report
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

A 30-year-old man developed invasive aspergillosis with cerebral and ocular involvement following treatment with ruxolitinib, tacrolimus, budesonide and prednisone for a cutaneous and digestive graft versus host disease. Additionally, he experienced lack of efficacy following antifungal treatment with posaconazole, voriconazole and amphotericin B for invasive aspergillosis [not all routes and dosages stated; durations of treatments to reactions onsets not stated].

The man had acute myeloblastic leukaemia in complete remission with minimal negative residual disease and secondary myelodysplastic syndrome. He was hospitalised on 6 October 2017 for bilateral pneumonia of mixed aetiology due to Pseudomonas aeruginosa (isolated in blood cultures and sputa) and Aspergillus sp. (isolati...


  1. Moruno-Rodriguez A, et al. Invasive aspergillosis manifesting as retinal necrosis in a patient treated with ruxolitinib. Archivos de la Sociedad Espanola de Oftalmologia 94: 237-241, No. 5, May 2019. Available from: URL: [Spanish; summarised from a translation]CrossRefGoogle Scholar

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© Springer International Publishing AG 2020

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