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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 50-year-old man developed Aspergillus mediastinitis during immunosuppressive therapy with prednisone and tacrolimus. Subsequently, he developed neuromuscular pain during treatment with voriconazole for Aspergillus mediastinitis [not all durations of treatments to reactions onsets stated].
The man, who had undergone heart transplant surgery one year prior, presented to the emergency department with mild cough and dysphonia for 1 month. He had been receiving immunosuppressive therapy with oral prednisone 10mg twice a day and tacrolimus 3mg in the morning and 2mg at night. He had developed constrictive pericarditis after 6 months of heart transplantation and had been treated with increasing doses of prednisone and concomitant colchicine. His medical history included type 2...
- Caron J, et al. Atypical presentation of aspergillus mediastinitis infection in a heart transplant patient: The importance of combined medical and surgical treatment. Experimental and Clinical Transplantation 17: 695-698, No. 5, Oct 2019. Available from: URL: http://doi.org/10.6002/ect.2018.0185 - CanadaCrossRefGoogle Scholar