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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
* Drug interaction
An adult man [exact age not stated] developed dyskinesia during treatment with levodopa/carbidopa and levodopa/benserazide for Parkinson's disease. Additionally, he developed aggravation of dyskinesia following the concomitant administration of entacapone and levodopa/benserazide for Parkinson's disease [not all dosages stated; durations of treatments to reactions onsets not stated].
The man was hospitalised on 2 May 2018 at the age of 69 years due to sudden loss of consciousness for 10 minutes, bradykinesia for 15 years and recurrent limb twitching with apnoea for >6 months. In 2008, he had been diagnosed with Parkinson's disease and had started receiving oral levodopa/benserazide [Madopar; levodopa/benserazide hydrochoride] tablets. Thereafter, movement...
- Yang X, et al. Parkinson's disease with paroxysmal breath holding and hypoxemia as the manifestation of dyskinesia: a case report. Chinese Journal of Neurology 52: 646-649, No. 8, Aug 2019. Available from: URL: http://doi.org/10.3760/cma.j.issn.1006-7876.2019.08.008 [Chinese; summarised from a translation] - China