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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A report described a 56-year-old man and 21-year-old woman, who developed DRESS syndrome while receiving anti-tubercular treatment with isoniazid, ethambutol, pyrazinamide and rifampicin [routes and outcomes not stated; not all dosages and durations of treatment to reaction onsets stated].
Patient 1: The 56-year-old man, who had a history of rheumatoid arthritis, developed pulmonary and lymph node tuberculosis. Subsequently, he started receiving anti-tubercular therapy with isoniazid, rifampicin, ethambutol and pyrazinamide. However, after 6 weeks, he was hospitalised due to fever, an extensive maculopapular rash, disseminated peripheral lymphadenopathy and pronounced facial and palmoplantar oedema. Laboratory tests showed high blood eosinophilia and increased AST and ALT...
- Coster A, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by first-line antituberculosis drugs: Two case reports and a review of the literature. Contact Dermatitis 81: 325-331, No. 5, Nov 2019. Available from: URL: http://doi.org/10.1111/cod.13296 - BelgiumCrossRefGoogle Scholar