- 104 Downloads
An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a case series, three patients including two men and one woman aged 61−77 years were described, who developed haemophagocytic lymphohistiocytosis (HLH) during treatment with ibrutinib. Additionally, these 3 patients exhibited lack of effect and died despite treatment with immune globulin, etoposide, dexamethasone, cyclophosphamide, ciclosporin or unspecified steroids [not all routes and dosages stated].
Case 1: A 77-year-old woman, who had lymphoplasmacytic lymphoma (LPL), had been receiving treatment with ibrutinib. Two weeks after starting ibrutinib, she developed pancytopenia, fevers, hyperbilirubinaemia and elevated liver enzymes. A bone marrow biopsy showed marked haemophagocytosis; however, LPL was not evident. Laboratory findings revealed the following: elevated...
- Ambinder AJ, et al. Ibrutinib-associated hemophagocytic lymphohistiocytosis: A case series from Johns Hopkins. American Journal of Hematology 94: E296-E299, No. 11, Nov 2019. Available from: URL: http://doi.org/10.1002/ajh.25611 - USA