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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 50-year-old woman acquired drug resistance to linezolid during its treatment for Staphylococcus epidermidis bacteraemia.
The woman presented with acute pain in the lumbar region and right groin which had occurred a few days prior. Her medical history included metabolic syndrome, class III obesity, hyperlipoproteinaemia, previously unknown type II diabetes mellitus, haemorrhoid surgery, arterial hypertension, suspected heart failure, nocturia, evening lower leg oedema and nicotine abuse. She had been receiving valsartan, amlodipine and hydrochlorothiazide. Considering tapping pain on the right side of the paravertebral space at the level of the lumbar spine and a diffuse abdominal pressure pain, magnetic resonance tomogram was performed which showed an inconspicuous finding,...
- Andres AH, et al. Linezolid resistance after bacteraemia with staphylococcus epidermidis - a standard linezolid therapy may lead to drug resistance in critically ill patients due to low serum concentration. [German]. Anasthesiologie and Intensivmedizin 60: 410-415, No. 7, Jul-Aug 2019. Available from: URL: http://doi.org/10.19224/ai2019.410 [German; summarised from a translation] - Germany