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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 21-year-old man developed amnestic syndrome, hypoxia, hippocampal injury and strong drug craving following fentanyl abuse [dosages and duration of treatment to reactions onsets not stated; not all outcomes stated].
The man, who had a history of opioid abuse, presented at an emergency department at the age of 25 years with acute-onset anterograde amnesia following purporated IV fentanyl use. On an anamnesis it was found that his abuse history began during adolescence with infrequent recreational prescription opioids [specific drug not stated], then progressed to diamorphine [heroin] and eventually to daily fentanyl use by his early 20s. His use of fentanyl was typically in combination with benzodiazepines and stimulants [specific drug not stated]. At the age of 21 years, he...
- Monroe Butler P, et al. An opioid-related amnestic syndrome with persistent effects on hippocampal structure and function. Journal of Neuropsychiatry and Clinical Neurosciences 31: 392-396, No. 4, Oct 2019. Available from: URL: http://doi.org/10.1176/appi.neuropsych.19010017 - USACrossRefGoogle Scholar