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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a prospective study involving 20 patients, who were recruited between January 2016 and April 2017 after phacoemulsification surgery, four patients [three women and one man; aged: 57−78 years] were described, who developed toxic retinopathy following treatment with cefuroxime to prevent postoperative endophthalmitis.
Patient 1: A 70-year-old woman, who had an age-related cataract and corneal oedema, underwent phacoemulsification combined with intraocular lens implantation under anaesthesia. Thereafter, she received cefuroxime [cefuroxime sodium] 1 mg/0.1mL was injected into the anterior chamber at the end of surgery. Post-operatively, she received various concomitant medications. One day after surgery, she developed cefuroxime toxic retinopathy. Her corrected distance visual...