Interferon and antivirals
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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a case series of 2 patients, two men aged 56 years and 64 years were described, who developed graft versus host disease (GVHD) following administration of ledipasvir/sofosbuvir or ribavirin and unspecified interferon for hepatitis C virus infection. Additionally, the 56-year-old man also developed diarrhoea following administration of immunosuppressant drug therapy with mycophenolate mofetil [dosages, routes, times to reactions onsets not stated; not all outcomes stated].
Case 1: The 56-year-old man underwent orthotropic liver transplantation for decompensated cirrhosis secondary to hepatitis C virus (HCV). His maintenance immunosuppressant drug therapy included mycophenolate mofetil along with concurrent tacrolimus. The donor was cytomegalovirus seropositive. One month...
- Advani SD, et al. Two Cases and a Review of Graft-Versus-Host Disease and the Role of Hepatitis C Treatment in Liver Transplant Patients. Progress in Transplantation (Aliso Viejo, Calif.) 28: 267-270, No. 3, Sep 2018. Available from: URL: http://doi.org/10.1177/1526924818781558 - USACrossRefGoogle Scholar