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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 27-year-old woman developed opioid use disorder and opioid withdrawal symptoms following abuse of hydromorphone, morphine and oxycodone in a clinical setting under malingering. Additionally, she also abused clonazepam [dosages and durations of treatments to reactions onsets not stated; not all routes stated].
The woman presented to an emergency department in a hospital citing a suicide attempt three hours after ingestion of glass shards with blood in vomit, nausea, diffuse abdominal discomfort and throat, chest, and abdominal pain. Since 2 months prior to the presentation, she had been ingesting clonazepam daily, and she had started using IV heroin daily 3 weeks prior to the admission. She reported that she needed help about her substance use and suicidality (malingering...
- Nisavic M, et al. Case 26-2019: A 27-Year-Old Woman with Opioid Use Disorder and Suicidal Ideation. New England Journal of Medicine 381: 763-771, No. 8, 22 Aug 2019. Available from: URL: http://doi.org/10.1056/NEJMcpc1904043 - USA