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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a report, two men aged 54 years and 77 years were described, who developed acute migratory inflammatory polyarthritis during antiplatelet treatment with clopidogrel for post-percutaneous intervention thrombosis prophylaxis [routes and dosages not stated].
Case 1: A 54-year-old man presented to the emergency room with a 2-week history of bilateral shoulder pain, left hand pain and swelling. Two weeks prior to the presentation, he had undergone a percutaneous intervention (PCI) and drug-eluting stent placement (DES) for ST-elevation myocardial infarction. He received a loading dose of clopidogrel and then continued on dual-antiplatelet therapy with clopidogrel and aspirin for post-myocardial infarction thrombosis prophylaxis. His concomitant medications included warfarin...
- Ayesha B, et al. Clopidogrel-associated migratory inflammatory polyarthritis. American Journal of Case Reports 20: 489-492, 10 Apr 2019. Available from: URL: http://doi.org/10.12659/AJCR.911598 - USA