- 29 Downloads
An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 44-year-old woman developed heart failure and non-ischaemic cardiomyopathy during treatment with gabapentin for pain.
The woman, who had a medical history of anxiety and endometriosis, tripped and fell on her left side leading to leg injury. MRI showed stenosis at L4-L5 due to a broad‐based disc bulge. Subsequently, she started receiving oral gabapentin 300mg three times a day for pain. Within 3 weeks of gabapentin initiation, she developed fatigue and progressive shortness of breath. Two months following gabapentin initiation, she presented to the emergency room with a profound shortness of breath and cough. At the time of admission, she had been receiving various concomitant medications. Her N-terminal pro-brain natriuretic peptide (NT-proBNP) was 2025 pg/mL. An ECG revealed...
- Tellor KB, et al. A rare case of a gabapentin-induced cardiomyopathy. Journal of Clinical Pharmacy and Therapeutics 44: 644-646, No. 4, Aug 2019. Available from: URL: http://doi.org/10.1111/jcpt.12840 - USA