- 17 Downloads
An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a case series, two girls were described, out of whom a 15-year-old girl developed motor and sensory polyneuropathy during treatment with vincristine, and ototoxicity and hepatotoxicity during treatment with cisplatin, cyclophosphamide, filgrastim, lomustine, mesna, vincristine and vinblastine, whereas a 14-year-old girl developed peripheral neuropathy during treatment with vincristine, and hepatotoxicity during treatment with cisplatin, cyclophosphamide, filgrastim, lomustine, mesna, vincristine and vinblastine for medulloblastoma [routes not stated; not all dosages, durations of treatments to reactions onset and outcomes stated].
Case 1: A 15-year-old girl, who had group 4 non-metastatic medulloblastoma, started receiving chemotherapy as per CCG9961A protocol which comprised...
- Nobre L, et al. Effective and safe tumor inhibition using vinblastine in medulloblastoma. Pediatric Blood and Cancer 66: e27694, No. 6, Jun 2019. Available from: URL: http://doi.org/10.1002/pbc.27694 - Canada