Reactions Weekly

, Volume 1753, Issue 1, pp 45–45 | Cite as


Various toxicities: 4 case reports
Case report
Author Information

An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

A case series described 4 patients (3 women and 1 man) aged 50−68 years, who developed acute kidney injury, nausea, diarrhoea or drug resistance during treatment with aciclovir [acyclovir], brincidofovir, cidofovir, foscarnet or ganciclovir [not all routes stated] for cytomegalovirus (CMV) or herpes simplex virus (HSV) infections [not all time to reactions onsets and outcomes stated].

Patient 1: A 68-year-old woman was diagnosed with stage III follicular lymphoma. She received unspecified chemotherapy and achieved complete remission. After the fourth cycle of chemotherapy, she developed fever and CMV antigenaemia. Subsequently, she started receiving IV foscarnet 60 mg/kg/dose every 8 hours with a total of 5 doses of immunoglobulin every other day. She was CMV Ag negative...


  1. El-Haddad D, et al. Brincidofovir (CMX-001) for refractory and resistant CMV and HSV infections in immunocompromised cancer patients: A single-center experience. Antiviral Research 134: 58-62, Oct 2016. Available from: URL: - USA

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