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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A man in his late 50s [exact age not stated] developed Capnocytophaga canimorsus infection to bilateral prosthetic knee following treatment with prednisone and rituximab.
The man presented with a 2-year history of bilateral knee pain and swelling at the age of 59 years. Five years prior to the presentation, he underwent bilateral staged total knee arthroplasties (TKAs) for osteoarthrosis, and after 3-years, progressive pain and swelling in both knees were noted. Four years after prosthesis implantation, he underwent bilateral staged polyethylene liner exchanges to address the pain and swelling without improvement. At the time of revision arthroplasty, pre-operatively and intra-operative synovial fluid (SF) cultures were negative. Due to the ongoing symptoms, he was treated with...
- Noelle Larson A, et al. Case report: Capnocytophaga canimorsus a novel pathogen for joint arthroplasty. Clinical Orthopaedics and Related Research 467: 1634-1638, No. 6, Jun 2009. Available from: URL: http://doi.org/10.1007/s11999-008-0658-9 - USA