- 10 Downloads
An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 32-year-old man developed encephalitis during treatment with daclizumab for relapsing-remitting multiple sclerosis (RRMS). Additionally, six patients (1 man and 5 women) aged 30−51 years were described, who developed DRESS syndrome, acute disseminated encephalomyelitis, encephalitis, CNS manifestation, inflammatory demyelinating CNS process or CNS vasculitis during treatment with daclizumab for MS. Out of these 6 patients, five patients data was retrieved from Paul Ehrlich Institute, Federal Institute for Vaccines and Biomedicines, Germany [dosages, routes and durations of treatments to reactions onset not stated].
Patient 1: A 51-year-old man, who had MS started receiving daclizumab (retrieved from Paul Ehrlich Institute, Federal Institute for Vaccines and Biomedicines,...
- Luessi F, et al. GFAPalpha IgG-associated encephalitis upon daclizumab treatment of MS. Neurology: Neuroimmunology and NeuroInflammation 5: No. 5, Sep 2018. Available from: URL: http://doi.org/10.1212/NXI.0000000000000481 - GermanyGoogle Scholar