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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 3-year-old boy developed renal abscess secondary to Candida tropicalis infection during treatment with dexamethasone, vincristine, prednisolone, daunorubicin, methotrexate, asparaginase, hydrocortisone and cytarabine for B cell acute lymphoblastic leukaemia [not all routes stated, dosages and duration of treatments to reactions onsets not stated].
The boy presented with bloody diarrhoea, petechiae, pallor and several weeks of fever and was diagnosed with precursor-B cell acute lymphoblastic leukaemia with hyperdiploidy. He started receiving induction chemotherapy including dexamethasone (days 1−4), prednisolone (days 5−35), vincristine (days 5, 12, 19, 26), daunorubicin (day 5), asparaginase [L-asparaginase] (alternate day on days 6−24), and intrathecal cytarabine,...
- Rosa Duque JS, et al. Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment. International Journal of Infectious Diseases 81: 110-113, Apr 2019. Available from: URL: http://doi.org/10.1016/j.ijid.2019.02.002 - ChinaCrossRefPubMedGoogle Scholar