Reactions Weekly

, Volume 1748, Issue 1, pp 62–62 | Cite as


Adrenal insufficiency: 3 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a study involving 10 infants (study conducted between 2007 and 2017), three infants (one female infant and two male infants) aged 8 months−2 years and 8 months were described, who developed adrenal insufficiency during treatment with busulfan, cyclophosphamide, cytarabine, dexamethasone, etoposide, fluconazole, hydrocortisone, melphalan, methotrexate or prednisone for acute myeloblastic leukaemia or acute lymphoblastic leukaemia [not all routes and dosages stated; duration of treatments to reaction onset not stated].

Patient 1: A boy was diagnosed with acute myeloblastic leukaemia at birth. He received two courses of chemotherapy with busulfan, fludarabine and melphalan. He had graft-versus-host disease (GVHD) and underwent haematopoietic stem cell transplantation (HSCT),...


  1. Moritani K, et al. Prolonged adrenal insufficiency after high-dose glucocorticoid in infants with leukemia. Pediatric Hematology and Oncology 35: 355-361, No. 5-6, 2018. Available from: URL: -JapanCrossRefGoogle Scholar

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© Springer International Publishing AG 2019

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