Reactions Weekly

, Volume 1744, Issue 1, pp 37–38 | Cite as

Antiepileptic drugs

Lack of efficacy during treatment of status epilepticus: 12 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a retrospective, observational, cohort study of patients from adult status epilepticus registry between April 2006 to October 2017, 12 patients (7 women and 5 men) aged 20−90 years were described, who exhibited lack of efficacy during treatment of status epilepticus with carbamazepine, clobazam, clonazepam, ketamine, lacosamide, lamotrigine, levetiracetam, midazolam, oxcarbazepine, perampanel, phenytoin, pregabalin, propofol, thiopental-sodium, topiramate, valproic-acid or zonisamide [dosages and routes not stated].

Patient 1: The 25-year-old woman, who was diagnosed with N-methyl-D-aspartate receptor antibody (NMDA) encephalitis, developed an episode of status epilepticus (generalised convulsion) and received treatment with clonazepam, levetiracetam, carbamazepine and...


  1. Pantazou V, et al. Intravenous Corticosteroids as an Adjunctive Treatment for Refractory and Super-Refractory Status Epilepticus: An Observational Cohort Study. CNS Drugs 33: 187-192, No. 2, Feb 2019. Available from: URL: - SwitzerlandCrossRefPubMedGoogle Scholar

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© Springer International Publishing AG 2019

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