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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 51-year-old woman developed increased BP, slight increase in anti-nuclear antibody, shortening of prothrombin time and reduction of activated partial thromboplastin time during treatment with methylprednisolone for recurrence of neuromyelitis optica spectrum disorder; she further developed pontine haemorrhage and posterior reversible encephalopathy syndrome due to the increased BP [durations of treatment to reactions onsets not stated, not all outcomes stated].
The woman, who had dyslipidemia and hypertension, presented with blindness in the left eye, and was referred to the hospital. At the age of 35-years, she was diagnosed with optic neuritis and received IV methylprednisolone therapy. At the age of 35 and 40-years, she developed recurrent left visual acuity impairment and...
- Kamo H, et al. Pontine hemorrhage accompanied by neuromyelitis optica spectrum disorder. Journal of Neuroimmunology 330: 19-22, 15 May 2019. Available from: URL: http://doi.org/10.1016/j.jneuroim.2019.01.020 - Japan